Abstract
This study investigated the role of neurokinin 1 receptors (NK1R) in inflammatory cutaneous orofacial pain. The effects of subcutaneous and intracisternal administration of the NK1R antagonist SR140333 on the face rubbing response provoked by injection of 50 µl of 1.5% formalin into the vibrissa pad were examined. Subcutaneous administration of SR140333 (5, 15, 30 mg/kg) induced a dose-related depressant effect on both the first and second phases of the formalin test. In contrast, intracisternal administration of SR140333 (10, 30, 60, 90 μg) produced a decrease only on the second phase with an apparent ceiling effect at approximately 50%. These data suggest that persistent nociceptive effects associated with orofacial cutaneous inflammation depend at least in part on the activation of NK1R.
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Acknowledgements
The authors are grateful to Drs. L. Villanueva and D. Voisin for comments on the manuscript. This work was supported by Délégation Générale pour l'Armement and l'Institut UPSA de la Douleur.
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Luccarini, P., Henry, M., Alvarez, P. et al. Contribution of neurokinin 1 receptors in the cutaneous orofacial inflammatory pain. Naunyn-Schmiedeberg's Arch Pharmacol 368, 320–323 (2003). https://doi.org/10.1007/s00210-003-0799-z
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DOI: https://doi.org/10.1007/s00210-003-0799-z