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Perspectives and challenges of antioxidant therapy for atrial fibrillation

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Abstract

Atrial fibrillation (AF) is the most common sustained arrhythmia associated with significant morbidity and mortality. The mechanisms underlying the pathogenesis of AF are poorly understood, although electrophysiological remodeling has been described as an important initiating step. There is growing evidence that oxidative stress is involved in the pathogenesis of AF. Many known triggers of oxidative stress, such as age, diabetes, smoking, and inflammation, are linked with an increased risk of arrhythmia. Numerous preclinical studies and clinical trials reported the importance of antioxidant therapy in the prevention of AF, using vitamins C and E, polyunsaturated fatty acids, statins, or nitric oxide donors. The aim of our work is to give a current overview and analysis of opportunities, challenges, and benefits of antioxidant therapy in AF.

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Authors and Affiliations

  1. Institute of Biology, Genetics and Medical Genetics, Faculty of Medicine, Comenius University and University Hospital, Bratislava, Slovak Republic, Slovakia

    Iveta Gasparova

  2. Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, Martin, Slovak Republic, Slovakia

    Peter Kubatka & Vanda Valentova

  3. Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic

    Radka Opatrilova & Peter Kruzliak

  4. 2nd Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia

    Martin Caprnda

  5. Department of Cardiology, National Institute of Cardiovascular Diseases, Bratislava, Slovakia

    Slavomira Filipova

  6. Faculty of Medicine, University of Oviedo, Central University of Asturias (HUCA), Oviedo, Spain

    Luis Rodrigo

  7. Hypertension in Africa Research Team (HART), North-West University, Potchefstroom Campus, Potchefstroom, South Africa

    Leone Malan

  8. Department of Functional Sciences, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania

    Ioana Mozos

  9. Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Safarik University, Kosice, Slovakia

    Miroslava Rabajdova

  10. Clinic of Neurology, Jessenius Faculty of Medicine, Comenius University and University Hospital in Martin, Martin, Slovak Republic

    Vladimir Nosal

  11. Department of Endocrinology, Bogomolets National Medical University, Kyiv, Ukraine

    Nazarii Kobyliak

  12. Institute of Histology and Embryology, Faculty of Medicine, University of Ljublana, Ljublana, Slovenia

    Daniel Petrovic

  13. Department of Thoracic Surgery, Medical University of Silesia, Zabrze, Poland

    Mariusz Adamek

  14. 2nd Department of Surgery, Faculty of Medicine, Masaryk University, Brno, Czech Republic

    Peter Kruzliak

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  1. Iveta Gasparova
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  2. Peter Kubatka
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  3. Radka Opatrilova
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  4. Martin Caprnda
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  5. Slavomira Filipova
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  6. Luis Rodrigo
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  7. Leone Malan
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  8. Ioana Mozos
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  12. Vanda Valentova
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  13. Daniel Petrovic
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  14. Mariusz Adamek
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  15. Peter Kruzliak
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Correspondence to Peter Kruzliak.

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Gasparova, I., Kubatka, P., Opatrilova, R. et al. Perspectives and challenges of antioxidant therapy for atrial fibrillation. Naunyn-Schmiedeberg's Arch Pharmacol 390, 1–14 (2017). https://doi.org/10.1007/s00210-016-1320-9

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  • DOI: https://doi.org/10.1007/s00210-016-1320-9

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