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Effect of 1,25(OH)2 Vitamin D3 on Circulating Insulin-Like Growth Factor-I and β2 Microglobulin in Patients with Osteoporosis

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Abstract

To test the hypothesis that growth factors mediate the stimulatory effect of 1,25(OH)2vitamin D3 [1,25(OH)2D3] on bone remodeling in osteoporosis, the authors studied the effect of the secosteroid administration in two doses (1 μg/day and 2 μg/day) for 14 days on circulating insulin-like growth factor-I (IGF-I), β2 microglobulin, and osteocalcin in 18 osteoporotic women. The biological effectiveness of the treatment was controlled by a decline of serum intact parathyroid hormone. Compared with the values before treatment, 1,25(OH)2D3 increased means of plasma IGF-I, β2 microglobulin, and serum osteocalcin significantly; however, the effects were only apparent after the higher dose of the drug (169 ± 26 versus 134 ± 28 ng/ml, P < 0.01; 2.08 ± 0.1 versus 1.92 ± 0.1 μg/ml, P < 0.05; and 8.5 ± 1.3 versus 5.4 ± 1.1 ng/ml, P < 0.01, respectively). The authors conclude that exogenous 1,25(OH)2D3 promotes the production of IGF-I and β2 microglobulin in osteoporotic patients in parallel to the marker of osteoblastic function, osteocalcin, which supports the tested hypothesis.

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  1. Institute of Endocrinology, Národní 8,, 116 94, Prague 1, Czech Republic

    R. L. Kancheva

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  1. R. L. Kancheva
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Kancheva, R.L. Effect of 1,25(OH)2 Vitamin D3 on Circulating Insulin-Like Growth Factor-I and β2 Microglobulin in Patients with Osteoporosis. Calcif Tissue Int 60, 236–239 (1997). https://doi.org/10.1007/s002239900221

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  • DOI: https://doi.org/10.1007/s002239900221

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