Skip to main content
SpringerLink
Log in

Bacterial pneumonia can increase serum concentration of clozapine

  • Pharmacokinetics and Disposition
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Abstract.

Concentrations of serum clozapine, c-reactive protein (CRP) and alpha1 acid glycoprotein were greatly increased during a bacterial pneumonia in a 53-year-old woman. As the pneumonia subsided, and CRP and alpha1 acid glycoprotein normalised, serum clozapine concentration also decreased to the previous level. An increased serum clozapine and a lowered N-desmethylclozapine to clozapine ratio during the infection suggest a decreased cytochrome P 450 (CYP)1A2 activity. Cytokine-mediated CYP1A2 suppression is discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Clinical Pharmacology, University of Helsinki, Haartmaninkatu 4, 00290 Helsinki, Finland, , , , ,

    K. Raaska &  P. Neuvonen

  2. Kellokoski Hospital, 04500 Kellokoski, Finland, , , , ,

    V. Raitasuo &  M. Arstila

Authors
  1. K. Raaska
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. Raitasuo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Arstila
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Neuvonen
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Accepted in revised form: 14 May 2002

Electronic Publication

Rights and permissions

Reprints and permissions

About this article

Cite this article

Raaska, .K., Raitasuo, .V., Arstila, .M. et al. Bacterial pneumonia can increase serum concentration of clozapine. Eur J Clin Pharmacol 58, 321–322 (2002). https://doi.org/10.1007/s00228-002-0486-x

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00228-002-0486-x

Search

Navigation