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Strong association between HLA-B*1502 and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in mainland Han Chinese patients

  • Pharmacogenetics
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Abstract

Purpose

The purpose of this study is to examine the association of HLA-B*1502 allele with CBZ-induced SJS/TEN in the mainland Han Chinese population.

Methods

HLA-B*1502 genotyping with sequence-specific primer polymerase chain reaction (PCR-SSP) and PCR-sequencing based typing (PCR-SBT) was performed on 17 CBZ-induced SJS/TEN patients, 21 CBZ-tolerant controls, and 185 healthy controls recruited during 2008–2010.

Results

HLA-B*1502 allele was present in 94.1% (16/17) of CBZ-SJS/TEN patients, 9.5% (2/21) of CBZ-tolerant patients, and 9.2% (17/185) of healthy controls. The risk of CBZ-induced SJS/TEN was significantly higher (P < 0.01) in the patients with HLA-B*1502. One CBZ-induced SJS patient tested negative for HLA-B*1502, and the test result showed HLA-B*3503/B*4601.

Conclusions

We found a strong association between HLA-B*1502 and CBZ-induced SJS/TEN in the Han Chinese population from central and northern China. Combined with previous studies of the southern Han Chinese subpopulation, our results suggest that HLA-B*1502 is strongly associated with CBZ-induced SJS/TEN in the whole Han Chinese population.

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Acknowledgments

This project was supported by a grant from the National Natural Science Foundation of China (no. 30973597), the Key Funds for Major State Basic Research Program of Suzhou (SYS201001), and Chinese National High Technology Research and Development Program 863 (2008AA02Z436). We confirm that we have read the Journal’s position on issues involved in ethical publication and affirm that this report is consistent with those guidelines. None of the authors has any conflict of interest to disclose.

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Authors and Affiliations

  1. Department of Clinical Pharmacology Research Lab, The First Affiliated Hospital of Soochow University, Suzhou, China

    Yan Zhang, Wei Peng, Ling Xue, Xiao-Xian Zheng & Li-Yan Miao

  2. Department of Pharmacology and Laboratory of Aging and Nervous Diseases, Soochow University School of Pharmacy, Suzhou, China

    Jin Wang

  3. Hospital of Dermatology, Chinese Academy of Medical Sciences, Nanjing, China

    Guo-Qing Shen & Chun-Yan Gong

  4. Department of Pharmacy, Shengjing Hospital of China Medical University, Shenyang, China

    Li-Mei Zhao & Xiao-Jing HE

Authors
  1. Yan Zhang
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  2. Jin Wang
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  3. Li-Mei Zhao
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  4. Wei Peng
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  5. Guo-Qing Shen
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  6. Ling Xue
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  7. Xiao-Xian Zheng
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  8. Xiao-Jing HE
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  9. Chun-Yan Gong
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  10. Li-Yan Miao
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Corresponding author

Correspondence to Li-Yan Miao.

Additional information

Yan Zhang and Jin Wang contributed equally to this work.

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Zhang, Y., Wang, J., Zhao, LM. et al. Strong association between HLA-B*1502 and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in mainland Han Chinese patients. Eur J Clin Pharmacol 67, 885–887 (2011). https://doi.org/10.1007/s00228-011-1009-4

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  • DOI: https://doi.org/10.1007/s00228-011-1009-4

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