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Non invasive in vivo study of the maturation of CYP IIIA in neonates and infants

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Abstract

Objective: Cytochrome P450 III (CYP III) has previously been demonstrated in vitro in fetal liver.

Methods:

A study was performed in 7 premature, 13 term neonates and 30 infants to assess whether or not maturation had any influence on CYP IIIA activity in children from birth to 1 year of age. A simple non invasive procedure was used (6 βOHF/FF concentration ratio in a morning spot urine sample).

Results:

The 6 βOHF/FF ratio was 7.2, 7.9 and 5.0 in premature and term neonates and infants, respectively. CYP IIIA activity is present at birth, with a 6 βOHF/FF ratio comparable to adults. Its activity seemed lower in infants. This might be due to the decrease in CYP IIIA7 activity during maturation after birth, which might be more rapid than the increase in CYP IIIA3/4 activity.

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Authors and Affiliations

  1. Département de Pharmacologie Clinique Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, 82 Avenue Denfert Rochereau, F-75674 Paris Cedex 14, France, , , , , , VC

    F. Vauzelle-Kervroedan, E. Rey, A. Pariente-Khayat, T. Bienvenu, G. Olive & G. Pons

  2. Service de Pédiatrie Générale, Hópital Saint-Vincent de Paul, 82 Avenue Denfert Rochereau, F-75674 Paris Cédex 14, France, , , , , , VC

    J. Badoual

Authors
  1. F. Vauzelle-Kervroedan
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  2. E. Rey
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  3. A. Pariente-Khayat
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  4. T. Bienvenu
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  5. J. Badoual
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  6. G. Olive
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  7. G. Pons
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Additional information

Received: 1 August 1995/ Accepted in revised form: 23 February 1996

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Vauzelle-Kervroedan, F., Rey, E., Pariente-Khayat, A. et al. Non invasive in vivo study of the maturation of CYP IIIA in neonates and infants. E J Clin Pharmacol 51, 69–72 (1996). https://doi.org/10.1007/s002280050162

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  • DOI: https://doi.org/10.1007/s002280050162

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