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Investigation of the Hepatoprotective Effects of Sesame (Sesamum indicum L.) in Carbon Tetrachloride-Induced Liver Toxicity

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Abstract

More than 600 chemicals can cause damage in liver, one of which is carbon tetrachloride (CCl4). Hepatoprotective agents could prevent tissue damage and reduce morbidity and mortality rates; such agents may include alternative or folkloric treatments. We investigated sesame (Sesamum indicum L.) for its hepatoprotective effect in CCl4-induced experimental liver damage. To this end, 0.8 mg/kg of sesame fixed oil was provided intraperitoneally to rats whose livers were damaged by CCl4. Tissue and blood samples were taken at the end of the experiments and evaluated histologically and biochemically. Ballooning degenerations and an increase in lipid droplets in liver parenchyma and increases in serum alanine transaminase, aspartate transaminase, and bilirubin were found in the CCl4 group. Biochemical and histopathological findings in the sesame fixed oil treated group were not significantly different from the CCl4 group. Sesame did not show a hepatoprotective effect in CCl4-induced liver toxicity.

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Authors and Affiliations

  1. Department of Histology and Embryology, Faculty of Medicine, Yüzüncü Yıl University, Van, Turkey

    Nureddin Cengiz

  2. Department of Biophysics, Faculty of Medicine, Yüzüncü Yıl University, Van, Turkey

    Servet Kavak & Hava Bektaş

  3. State Hospital, Bitlis, Turkey

    Ali Güzel

  4. Department of Drug and Pharmacy, Ministry of Health, Ankara, Turkey

    Hanefi Özbek

  5. Department of Biophysics, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey

    Aydın Him

  6. Department of Histology and Embryology, Faculty of Medicine, Selcuk University, Konya, Turkey

    Ender Erdoğan

  7. Department of Biochemistry, Faculty of Medicine, Selcuk University, Konya, Turkey

    Ragıb Balahoroğlu

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  1. Nureddin Cengiz
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  2. Servet Kavak
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  3. Ali Güzel
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  4. Hanefi Özbek
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  5. Hava Bektaş
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  6. Aydın Him
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  7. Ender Erdoğan
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  8. Ragıb Balahoroğlu
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Correspondence to Nureddin Cengiz.

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Cengiz, N., Kavak, S., Güzel, A. et al. Investigation of the Hepatoprotective Effects of Sesame (Sesamum indicum L.) in Carbon Tetrachloride-Induced Liver Toxicity. J Membrane Biol 246, 1–6 (2013). https://doi.org/10.1007/s00232-012-9494-7

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  • DOI: https://doi.org/10.1007/s00232-012-9494-7

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