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TRPM channels: same ballpark, different players, and different rules in immunogenetics

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Abstract

Transient receptor potential (TRP) channels belong to a large family of cation channels and are the “border guards” predominantly localized to the plasma membrane. Research over the years has considerably and highly developed the knowledge of expression and functional aspects of the TRPM channels. A closer look at the channel dynamics has dismantled undeniable substantiation for multifaceted roles for TRPM channel-mediated extracellular Ca(2+) influx in several physiological and pathophysiological functions. Given the wealth of literature unfolding the multiple roles of TRP channels in physiology in a very extensive range of different mammalian tissues, this review confines itself to the literature describing the multiple roles of TRPM channels in diabetes, smooth muscle cell regulation, immunological responses, and emerging aspects of cancer. We also focus on differential activities of TRPM channels after post-transcriptional and post-translational processing and their exquisite roles at various cellular and molecular levels.

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  1. Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Punjab, Pakistan

    Ammad Ahmad Farooqi, Mohammed Khalid Javeed, Zeeshan Javed, Asma M. Riaz, Shahzeray Mukhtar, Sehrish Minhaj, Sana Abbas & Shahzad Bhatti

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  1. Ammad Ahmad Farooqi
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  2. Mohammed Khalid Javeed
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  3. Zeeshan Javed
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Correspondence to Ammad Ahmad Farooqi or Shahzad Bhatti.

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Farooqi, A.A., Javeed, M.K., Javed, Z. et al. TRPM channels: same ballpark, different players, and different rules in immunogenetics. Immunogenetics 63, 773–787 (2011). https://doi.org/10.1007/s00251-011-0570-4

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