Fat replacement of Hodgkin disease of bone marrow after chemotherapy: report of three cases

Abstract

 Three cases are presented with fat replacement of Hodgkin disease of bone marrow after chemotherapy. Magnetic resonance imaging on admission demonstrated low-signal intensity of lesions on T1-weighted images and high-signal intensity on short inversion time inversion-recovery images. Seven lesions were observed, five of which were located in the spine and two in the pelvis. All lesions showed reversal of signal intensities after completion of chemotherapy. T1-weighted fat saturation images confirmed the fatty nature of the lesions after treatment. All patients had a nodular sclerosis, Hodgkin disease, type 2. One can speculate as to whether the conversion to fat actually represents a particularly successful result of chemotherapy.