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Influence of Rifampin on Capsule Formation Around Silicone Implants in a Rat Model

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Abstract

This study investigated the effect of rifampin on the thickness of capsules around silicone implants by bactericidal activity against Stapylococcus epidermidis. Silicone blocks (1 × 1 cm) were placed into pockets created for each of the 40 rats included in the study. In group 1, the operation was performed under aseptic conditions. In group 2, standard S. epidermidis was inoculated into the pocket, whereas rifampin and S. epidermidis were applied in group 3. In group 4, only rifampin was applied topically on implants. After 12 weeks, the peri-implant capsules were removed and examined under a photomicroscope and a scanning electron microscope. The mean thickness of the capsules was 63.307 μm in group 1, 111.538 μm in group 2, 43.076 μm in group 3, and 30.384 μm in group 4. The differences between groups 2 and 3 and groups 2 and 4 were found to be statistically significant (p < 0.001). Rifampin appears to be an agent for preventing peri-implant capsule formation.

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Authors and Affiliations

  1. Department of 2nd Plastic and Reconstructive Surgery, Ankara Numune Training and Research Hospital, Ankara, Turkey

    Ramazan Erkin Unlu M.D., Asu Deniz Yilmaz M.D., Hakan Orbay M.D. & Omer Sensoz M.D.

  2. Department of Histology and Embryology, Ankara University Faculty of Medicine, Ankara, Turkey

    Belgin Can M.D.

  3. Department of Anatomy, Ankara University Faculty of Medicine, Ankara, Turkey

    Ibrahim Tekdemir Ph.D.

  4. Bascavus Sokak 76/16 Kucukesat, Ankara, Turkey

    Asu Deniz Yilmaz M.D.

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  1. Ramazan Erkin Unlu M.D.
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Correspondence to Asu Deniz Yilmaz M.D..

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Unlu, R.E., Yilmaz, A.D., Orbay, H. et al. Influence of Rifampin on Capsule Formation Around Silicone Implants in a Rat Model. Aesth Plast Surg 31, 358–364 (2007). https://doi.org/10.1007/s00266-006-0248-8

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  • DOI: https://doi.org/10.1007/s00266-006-0248-8

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