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A case of localized Castleman's disease with systemic involvement: treatment and pathogenetic aspects

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Abstract

 A patient is presented who had Castleman's disease with constitutional symptoms, a palpable supraclavicular/axillar mass, and a microcytic anemia, among other laboratory abnormalities, including elevated levels of interleukin-6. Treatment consisted of irradiation of the involved area, with subsequent disappearance of all symptoms and normalization of the laboratory abnormalities. Iron kinetic studies demonstrated a hypoproliferative erythropoiesis, which normalized after radiotherapy. Hypoproliferative erythopoiesis could not be ascribed to serum inhibitors, since normal burst-forming units were observed in the absence or presence of autologous serum. The role of interleukin-6 in relation to Castleman's disease is highlighted.

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Medical Onocology, University Hospital Groningen, P.O.Box 30.001, NL-9700 RB Groningen, The Netherlands, , , , , , NL

    G. J. Veldhuis & E. G. E. de Vries

  2. Department of Radiotherapy, University Hospital Groningen, P.O. Box 30.001, NL-9700 R.B. Groningen, The Netherlands, , , , , , NL

    A. H. D. van der Leest

  3. Department of Internal Medicine, Division of Hematology, University Hospital Groningen, P.O. Box 30.001, NL-9700 R.B. Groningen, The Netherlands, , , , , , NL

    J. T. M. de Wolf & E. Vellenga

Authors
  1. G. J. Veldhuis
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  2. A. H. D. van der Leest
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  3. J. T. M. de Wolf
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  4. E. G. E. de Vries
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  5. E. Vellenga
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Received: 18 December 1995 / Accepted 27 March 1996

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Veldhuis, G., van der Leest, A., de Wolf, J. et al. A case of localized Castleman's disease with systemic involvement: treatment and pathogenetic aspects. Ann Hematol 73, 47–50 (1996). https://doi.org/10.1007/s002770050201

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  • DOI: https://doi.org/10.1007/s002770050201

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