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Arthritis models: usefulness and interpretation

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Abstract

Animal models of arthritis are used to better understand pathophysiology of a disease or to seek potential therapeutic targets or strategies. Focusing on models currently used for studying rheumatoid arthritis, we show here in which extent models were invaluable to enlighten different mechanisms such as the role of innate immunity, T and B cells, vessels, or microbiota. Moreover, models were the starting point of in vivo application of cytokine-blocking strategies such as anti-TNF or anti-IL-6 treatments. The most popular models are the different types of collagen-induced arthritis and arthritis in KBN mice. As spontaneous arthritides, human TNF-α transgenic mice are a reliable model. It is mandatory to use animal models in the respect of ethical procedure, particularly regarding the number of animals and the control of pain. Moreover, design of experiments should be of the highest level, animal models of arthritis being dedicated to exploration of well-based novelties, and never used for confirmation or replication of already proven concepts. The best interpretations of data in animal models of arthritis suppose integrated research, including translational studies from animals to humans.

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  1. Natacha Bessis and Patrice Decker contributed equally.

Authors and Affiliations

  1. INSERM UMR 1125 Sorbonne Paris Cité, Université Paris 13, 74 rue Marcel Cachin, 93000, Bobigny, France

    Natacha Bessis, Patrice Decker, Eric Assier, Luca Semerano & Marie-Christophe Boissier

  2. Service de Rhumatologie, Hôpital Avicenne, Assistance Publique-Hôpitaux de Paris (APHP), 125 rue de Stalingrad, 93000, Bobigny, France

    Luca Semerano & Marie-Christophe Boissier

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  1. Natacha Bessis
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This article is a contribution to the special issue on Immunopathology of Rheumatoid Arthritis - Guest Editors: Cem Gabay and Paul Hasler

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Bessis, N., Decker, P., Assier, E. et al. Arthritis models: usefulness and interpretation. Semin Immunopathol 39, 469–486 (2017). https://doi.org/10.1007/s00281-017-0622-4

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