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Serum visfatin concentrations in gestational diabetes mellitus and normal pregnancy

  • Maternal-Fetal Medicine
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Purpose

There is conflicting data regarding visfatin in gestational diabetes mellitus (GDM). The aim of the present study was to compare serum visfatin levels between patients with GDM and subjects with normal pregnancy and to evaluate its relationship with dietary intake and components of insulin-resistance syndrome.

Methods

Thirty-five patients with GDM (aged 31 ± 0.8 years, BMI = 29.6) and 35 age- and body mass index-matched healthy pregnant women (aged 29 ± 0.7 years, BMI = 28.6) between 24 and 28 weeks of gestation were studied. In addition to anthropometric and dietary intake assessments, measurements of fasting plasma levels of visfatin, glucose, insulin, hemoglobin A1c (HbA1c) and lipid profile were performed for all subjects.

Results

Plasma visfatin levels were significantly lower in pregnant women with GDM compared to healthy subjects (5.29 ± 0.47 vs. 7.76 ± 0.53, p = 0.001). After adjustment for age, maternal gestational age, body mass index, and macronutrients intake, GDM remained the independent predictor of serum visfatin concentrations (β = −1.2, p = 0.001). Serum visfatin levels were significantly correlated with log HbA1c values (r = −0.24, p = 0.03), even after adjustment for age and body mass index (β = −6.45, p = 0.05). No associations between visfatin and other parameters of the insulin-resistance syndrome as well as macronutrient intake were detectable.

Conclusions

Plasma visfatin concentrations are lower in patients with GDM and related to glycemic control reflected by HbA1c. Furthermore, visfatin does not seem to be correlated with dietary intake in pregnant women.

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Acknowledgments

This research has been supported by Tehran University of Medical Sciences and Health services grant. Also, we would like to thank obstetrics clinic staff of the Arash hospital, Tehran University of Medical Sciences, Tehran, Iran.

Conflict of interest

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Nutrition and Biochemistry, School of Public Health and Institute of Public Health Research, Tehran University of Medical Sciences, Poursina Ave., Qods St, 141556446, Tehran, Iran

    Neda Rezvan, Mohammad Javad Hosseinzadeh-Attar & Maryam Mazaherioun

  2. Students’ Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran

    Farzad Masoudkabir

  3. Department of Gynecology and Obstetrics, Roointan Arash Women’s Health Research and Educational Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Ashraf Moini

  4. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    Leila Janani

Authors
  1. Neda Rezvan
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  2. Mohammad Javad Hosseinzadeh-Attar
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  3. Farzad Masoudkabir
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Corresponding author

Correspondence to Mohammad Javad Hosseinzadeh-Attar.

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Rezvan, N., Hosseinzadeh-Attar, M.J., Masoudkabir, F. et al. Serum visfatin concentrations in gestational diabetes mellitus and normal pregnancy. Arch Gynecol Obstet 285, 1257–1262 (2012). https://doi.org/10.1007/s00404-011-2156-7

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  • DOI: https://doi.org/10.1007/s00404-011-2156-7

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