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The Munich 15-year follow-up study (MUFUSSAD) on first-hospitalized patients with schizophrenic or affective disorders: comparison of psychopathological and psychosocial course and outcome and prediction of chronicity

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Abstract

Given the limited explanatory power of the available neurobiological findings, results of long-term follow-up studies should still be considered as one criterion among others in the development of psychiatric classification systems regarding schizophrenia and affective disorders. A total of 323 first hospitalized inpatients of the Psychiatric Department of the University Munich were recruited at index time and followed up after 15 years. The full follow-up evaluation including several standardized assessment procedures (AMDP, PANSS, SANS, DAS, GAS) could be performed in 197 patients. The patients originally diagnosed according to ICD-9 were re-diagnosed according to ICD-10 and DSM-IV, using SCID among others. Schizophrenic patients had a much poorer outcome than affective or schizoaffective patients in terms of negative syndrome, deficit syndrome, psychosocial impairments and GAS results, and a higher prevalence of a chronic course. The logistic regression analyses performed to find optimized predictor combinations for the prognosis of a chronic course found, for example, the total Strauss–Carpenter Scale score, male gender and several other psychopathological syndromes to be relevant predictors. The findings reflect some long-term related validity for the differentiation between schizophrenia and affective disorders. The Strauss–Carpenter Scale, male gender as well as several psychopathological syndromes are the most relevant predictors for chronicity.

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Acknowledgments

Prof. Dr. Moeller has received grants or is a consultant for and on the speakership bureaus of AstraZeneca, Bristol-Myers Squibb, Eisai, Eli Lilly, GlaxoSmithKline, Janssen Cilag, Lundbeck, Merck, Novartis, Organon, Pfizer, Sanofi-Aventis, Schering-Plough, Schwabe, Sepracor, Servier and Wyeth.

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  1. Ronald Bottlender

    Present address: Department of Psychiatry, East London and the City Mental Health NHS Trust, London, UK

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  1. Department of Psychiatry, University of Munich, Nussbaumstrasse 7, 80336, Munich, Germany

    Hans-Jürgen Möller

  2. Clinic for Psychiatry and Psychotherapy II, University of Ulm, Ulm, Germany

    Markus Jäger

  3. Department of Psychiatry, University of Munich, Munich, Germany

    Michael Riedel, Michael Obermeier, Anton Strauss & Ronald Bottlender

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Möller, HJ., Jäger, M., Riedel, M. et al. The Munich 15-year follow-up study (MUFUSSAD) on first-hospitalized patients with schizophrenic or affective disorders: comparison of psychopathological and psychosocial course and outcome and prediction of chronicity. Eur Arch Psychiatry Clin Neurosci 260, 367–384 (2010). https://doi.org/10.1007/s00406-010-0117-y

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