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Intraoperative real-time 99mTc-sestamibi scintigraphy with miniature gamma camera allows minimally invasive parathyroidectomy without ioPTH determination in primary hyperparathyroidism

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Abstract

Background

Minimally invasive parathyroidectomy (MIP) is being widely accepted as the procedure of choice for the treatment of primary hyperparathyroidism (PHPT), which is caused by a parathyroid single adenoma in more than 80% of cases in some series. Preoperative location studies, like sestamibi scans, allow the proper identification of pathologic gland and intraoperative parathormone (ioPTH) assay is used to confirm the removal of the adenoma. We have studied the feasibility of a new miniature gamma camera (MGC) used intraoperatively to locate parathyroid adenomas and confirm its correct excision.

Materials and methods

Twenty patients with PHPT positively diagnosed by preoperative sestamibi scans underwent a MIP. In the first five patients, both ioPTH assay and the new hand-held MGC were used consecutively to locate and confirm the excision of the pathologic gland. For the next 15 cases, PTH was measured but not used intraoperatively for diagnosis and the MGC was the only diagnostic tool employed to perform the operation. Concordance between preoperative and intraoperative scintigraphy, surgical time, success rate, and complications are analyzed.

Results

All cases were operated on successfully by a MIP. After 1 year follow-up, the drop of PTH and the normalization of calcium levels confirmed the excision of all pathologic tissue. The MGC proved its usefulness in all patients offering accurate real-time intraoperative images for location and confirming the success of the procedure.

Conclusions

The MGC is a useful instrument in MIP for PHPT. It may be used as complementary to the standard tools used to date, or even replace them, at least in selected cases of single adenomas.

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Abbreviations

Ca:

calcium

P:

phosphorus

ioPTH:

Intraoperative quick PTH essay

LPS:

laser positioning system

MGC:

miniature gamma camera

MIP:

minimally invasive parathyroidectomy

PHPT:

primary hyperparathyroidism

PTH:

parathyroid hormone

SPECT:

single photon emission technique

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Acknowledgements

This work was partially funded by a grant for the Developing of Research Programmes in Matter of Health (S.P.-0037/2005) from the Conselleria de Sanitat de la Generalitat Valenciana.

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Authors and Affiliations

  1. Unit of Endocrinologic and Bariatric Surgery, Clinic University Hospital, Av. Blasco Ibanez, 17, 46010, Valencia, Spain

    Norberto Cassinello, Joaquin Ortega & Salvador Lledo

  2. Department of Surgery, Clinic University Hospital, University of Valencia, Av. Blasco Ibanez, 17, 46010, Valencia, Spain

    Joaquin Ortega & Salvador Lledo

Authors
  1. Norberto Cassinello
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  2. Joaquin Ortega
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  3. Salvador Lledo
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Corresponding author

Correspondence to Norberto Cassinello.

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Best of Endocrine Surgery in Europe 2009

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Cassinello, N., Ortega, J. & Lledo, S. Intraoperative real-time 99mTc-sestamibi scintigraphy with miniature gamma camera allows minimally invasive parathyroidectomy without ioPTH determination in primary hyperparathyroidism. Langenbecks Arch Surg 394, 869–874 (2009). https://doi.org/10.1007/s00423-009-0523-7

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  • DOI: https://doi.org/10.1007/s00423-009-0523-7

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