Abstract
This review summarizes the modulation of transient receptor potential (TRP) channels, by phosphoinositides. TRP channels are characterized by polymodal activation and a surprising complexity of regulation mechanisms. Possibly, most if not all TRP channels are modulated by phosphoinositides. Modulation by phosphatidylinositol 4,5-biphosphate (PIP2) has been shown in detail for TRP vanilloid (TRPV) 1, TRPV5, TRP melastatin (TRPM) 4, TRPM5, TRPM7, TRPM8, TRP polycystin 2, and the Drosophila TPR-like (TRPL) channels. This review describes mechanisms of modulation of TRP channels mainly by PIP2 and discusses some future challenges of this fascinating topic.
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Acknowledgment
We thank all members or our laboratories for always-helpful discussions. This work was supported by the Human Frontiers Science Programme (HFSP Research Grant Ref. RGP 32/2004), the Belgian Federal Government, the Flemish Government, the Onderzoeksraad KU Leuven (GOA 99/07, F.W.O. G.0214.99, F.W.O. G. 0136.00; F.W.O. G.0172.03, Interuniversity Poles of Attraction Program, Prime Ministers Office (IUAP; BN), and the American Heart Association, the Alexander and Alexandrine Sinsheimer Foundation, and the UMDNJ Foundation (TR).
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Rohacs, T., Nilius, B. Regulation of transient receptor potential (TRP) channels by phosphoinositides. Pflugers Arch - Eur J Physiol 455, 157–168 (2007). https://doi.org/10.1007/s00424-007-0275-6
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DOI: https://doi.org/10.1007/s00424-007-0275-6