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Anoctamins

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Abstract

Endogenous Ca2+-activated Cl− channels (CaCC) demonstrate biophysical and pharmacological properties that are well represented in cells overexpressing anoctamin 1 (Ano 1, TMEM16A), a protein that has been identified recently as CaCC. Proteins of the anoctamin family (anoctamin 1–10, TMEM16A-K) are widely expressed. The number of reports demonstrating their physiological and clinical relevance is quickly rising. Anoctamins gain additional interest through their potential role in cell volume regulation and malignancy. Available data suggest that Ano 1 forms stable dimers and probably liaise with accessory proteins such as calmodulin or other anoctamins. In order to understand how anoctamins produce Ca2+-activated Cl− currents, it will be necessary to obtain better insight into their molecular structure, interactions with partner proteins, and mode of activation.

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Acknowledgments

Supported by DFG SFB699/A7, TargetScreen2 (EU-FP6-2005-LH-037365), Deutsche Krebshilfe (Projekt-Nr.:7207561), and Mukoviszidose e.V. (Projekt-Nr.:S02/10). We thank Mrs. Brigitte Wild and Ms. Julia Redekopf for excellent technical assistance.

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Authors and Affiliations

  1. Institut für Physiologie, Universität Regensburg, Universitätsstraße 31, D-93053, Regensburg, Germany

    Karl Kunzelmann, Yuemin Tian, Joana Raquel Martins, Diana Faria, Patthara Kongsuphol, Jiraporn Ousingsawat & Rainer Schreiber

  2. Lehrstuhl für Physiologie und Pathophysiologie, Fakultät für Medizin, Universität Witten/Herdecke, Witten, Germany

    Frank Thevenod

  3. Institut für Anatomie und Zellbiologie, Molekulare Embryologie, Universität Freiburg, Freiburg im Breisgau, Germany

    Eleni Roussa

  4. Department of Cell Biology, Duke University Medical Center, Durham, NC, 27710, USA

    Jason Rock

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  1. Karl Kunzelmann
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Correspondence to Karl Kunzelmann.

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Kunzelmann, K., Tian, Y., Martins, J.R. et al. Anoctamins. Pflugers Arch - Eur J Physiol 462, 195–208 (2011). https://doi.org/10.1007/s00424-011-0975-9

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