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A metabolic–transcriptional network links sleep and cellular energetics in the brain

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Abstract

This review proposes a mechanistic link between cellular metabolic status, transcriptional regulatory changes and sleep. Sleep loss is associated with changes in cellular metabolic status in the brain. Metabolic sensors responsive to cellular metabolic status regulate the circadian clock transcriptional network. Modifications of the transcriptional activity of circadian clock genes affect sleep/wake state changes. Changes in sleep state reverse sleep loss-induced changes in cellular metabolic status. It is thus proposed that the regulation of circadian clock genes by cellular metabolic sensors is a critical intermediate step in the link between cellular metabolic status and sleep. Studies of this regulatory relationship may offer insights into the function of sleep at the cellular level.

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Abbreviations

NREMS:

Non-rapid eye movement sleep

SWA:

Slow wave activity

EEG:

Electroencephalographic/electroencephalogram

ATP:

Adenosine triphosphate

ADP:

Adenosine diphosphate

AMP:

Adenosine monophosphate

AMPK:

Adenosine monophosphate-activated protein kinase

cry:

Cryptochrome

per:

Period

NAD:

Nicotine adenine dinucleotide

HDAC:

Histone deacetylase

PARP:

Poly ADP-ribose polymerase

GSK3b:

Glycogen synthase kinase 3b

PPARs:

Peroxisome proliferator-activated receptors

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Acknowledgements

The author is supported by DARPA Young Faculty Award N66001-09-1-2117 and NINDS 1R15NS070734.

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  1. WWAMI Medical Education Program and Department Of Veterinary Comparative Anatomy, Pharmacology and Physiology, Washington State University, Spokane, WA, USA

    Jonathan P. Wisor

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This article is published as part of the Special Issue on Sleep.

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Wisor, J.P. A metabolic–transcriptional network links sleep and cellular energetics in the brain. Pflugers Arch - Eur J Physiol 463, 15–22 (2012). https://doi.org/10.1007/s00424-011-1030-6

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