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Pressure-overload-induced right heart failure

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Abstract

Although pulmonary arterial hypertension originates in the lung and is caused by progressive remodeling of the small pulmonary arterioles, patients die from the consequences of pressure-overload-induced right heart failure. Prognosis is poor, and currently there are no selective treatments targeting the failing right ventricle. Therefore, it is of utmost importance to obtain more insights into the mechanisms of right ventricular adaptation and the transition toward right heart failure. In this review, we propose that the same adaptive mechanisms, which initially preserve right ventricular systolic function and maintain cardiac output, eventually initiate the transition toward right heart failure.

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References

  1. Andersen A, Povlsen JA, Bøtker HE, Nielsen-Kudsk JE (2013) Right ventricular hypertrophy and failure abolish cardioprotection by ischaemic pre-conditioning. Eur J Heart Fail 15:1208–1214. doi:10.1093/eurjhf/hft105

    Article  CAS  PubMed  Google Scholar 

  2. Banerjee D, Haddad F, Zamanian RT, Nagendran J (2010) Right ventricular failure: a novel era of targeted therapy. Curr Heart Fail Rep 7:202–211. doi:10.1007/s11897-010-0031-7

    Article  PubMed  Google Scholar 

  3. Bers DM (2002) Cardiac excitation–contraction coupling. Nature 415:198–205. doi:10.1038/415198a

    Article  CAS  PubMed  Google Scholar 

  4. Bogaard HJ, Abe K, Vonk Noordegraaf A, Voelkel NF (2009) The right ventricle under pressure: cellular and molecular mechanisms of right-heart failure in pulmonary hypertension. Chest 135:794–804. doi:10.1378/chest.08-0492

    Article  CAS  PubMed  Google Scholar 

  5. Bogaard HJ, Mizuno S, Hussaini AAA, Toldo S, Abbate A, Kraskauskas D, Kasper M, Natarajan R, Voelkel NF (2011) Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats. Am J Respir Crit Care Med 183:1402–1410. doi:10.1164/rccm.201007-1106OC

    Article  CAS  PubMed  Google Scholar 

  6. Bogaard HJ, Natarajan R, Henderson SC, Long CS, Kraskauskas D, Smithson L, Ockaili R, McCord JM, Voelkel NF (2009) Chronic pulmonary artery pressure elevation is insufficient to explain right heart failure. Circulation 120:1951–1960. doi:10.1161/CIRCULATIONAHA.109.883843

    Article  PubMed  Google Scholar 

  7. Bogaard HJ, Natarajan R, Mizuno S, Abbate A, Chang PJ, Chau VQ, Hoke NN, Kraskauskas D, Kasper M, Salloum FN, Voelkel NF (2010) Adrenergic receptor blockade reverses right heart remodeling and dysfunction in pulmonary hypertensive rats. Am J Respir Crit Care Med 182:652–660. doi:10.1164/rccm.201003-0335OC

    Article  CAS  PubMed  Google Scholar 

  8. Brancaccio M, Fratta L, Notte A, Hirsch E, Poulet R, Guazzone S, De Acetis M, Vecchione C, Marino G, Altruda F, Silengo L, Tarone G, Lembo G (2003) Melusin, a muscle-specific integrin beta1-interacting protein, is required to prevent cardiac failure in response to chronic pressure overload. Nat Med 9:68–75. doi:10.1038/nm805

    Article  CAS  PubMed  Google Scholar 

  9. Brancaccio M, Guazzone S, Menini N, Sibona E, Hirsch E, De Andrea M, Rocchi M, Altruda F, Tarone G, Silengo L (1999) Melusin is a new muscle-specific interactor for beta(1) integrin cytoplasmic domain. J Biol Chem 274:29282–29288

    Article  CAS  PubMed  Google Scholar 

  10. Brimioulle S, Wauthy P, Ewalenko P, Rondelet B, Vermeulen F, Kerbaul F, Naeije R (2003) Single-beat estimation of right ventricular end-systolic pressure-volume relationship. Am J Physiol Heart Circ Physiol 284:H1625–H1630. doi:10.1152/ajpheart.01023.2002

    CAS  PubMed  Google Scholar 

  11. Bristow MR, Ginsburg R, Umans V, Fowler M, Minobe W, Rasmussen R, Zera P, Menlove R, Shah P, Jamieson S (1986) Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure. Circ Res 59:297–309

    Article  CAS  PubMed  Google Scholar 

  12. Bristow MR, Minobe W, Rasmussen R, Larrabee P, Skerl L, Klein JW, Anderson FL, Murray J, Mestroni L, Karwande SV (1992) Beta-adrenergic neuroeffector abnormalities in the failing human heart are produced by local rather than systemic mechanisms. J Clin Invest 89:803–815. doi:10.1172/JCI115659

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. Burkhoff D, Mirsky I, Suga H (2005) Assessment of systolic and diastolic ventricular properties via pressure-volume analysis: a guide for clinical, translational, and basic researchers. Am J Physiol Heart Circ Physiol 289:H501–H512. doi:10.1152/ajpheart.00138.2005

    Article  CAS  PubMed  Google Scholar 

  14. Chen IY, Wu JC (2011) Cardiovascular molecular imaging focus on clinical translation. Circulation 123:425–443. doi:10.1161/CIRCULATIONAHA.109.916338

    Article  PubMed Central  PubMed  Google Scholar 

  15. Chin KM, Kim NHS, Rubin LJ (2005) The right ventricle in pulmonary hypertension. Coron Artery Dis 16:13–18

    Article  PubMed  Google Scholar 

  16. D’Alonzo GE, Barst RJ, Ayres SM, Bergofsky EH, Brundage BH, Detre KM, Fishman AP, Goldring RM, Groves BM, Kernis JT (1991) Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med 115:343–349

    Article  PubMed  Google Scholar 

  17. Drake JI, Bogaard HJ, Mizuno S, Clifton B, Xie B, Gao Y, Dumur CI, Fawcett P, Voelkel NF, Natarajan R (2011) Molecular signature of a right heart failure program in chronic severe pulmonary hypertension. Am J Respir Cell Mol Biol 45:1239–1247. doi:10.1165/rcmb.2010-0412OC

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  18. Ecarnot-Laubriet A, De Luca K, Vandroux D, Moisant M, Bernard C, Assem M, Rochette L, Teyssier JR (2000) Downregulation and nuclear relocation of MLP during the progression of right ventricular hypertrophy induced by chronic pressure overload. J Mol Cell Cardiol 32:2385–2395. doi:10.1006/jmcc.2000.1269

    Article  CAS  PubMed  Google Scholar 

  19. Franco V (2012) Right ventricular remodeling in pulmonary hypertension. Heart Fail Clin 8:403–412. doi:10.1016/j.hfc.2012.04.005

    Article  PubMed  Google Scholar 

  20. Gan CT-J, Lankhaar J-W, Marcus JT, Westerhof N, Marques KM, Bronzwaer JGF, Boonstra A, Postmus PE, Vonk-Noordegraaf A (2006) Impaired left ventricular filling due to right-to-left ventricular interaction in patients with pulmonary arterial hypertension. Am J Physiol Heart Circ Physiol 290:H1528–H1533. doi:10.1152/ajpheart.01031.2005

    CAS  PubMed  Google Scholar 

  21. Grossman W, Jones D, McLaurin LP (1975) Wall stress and patterns of hypertrophy in the human left ventricle. J Clin Invest 56:56–64. doi:10.1172/JCI108079

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  22. Haddad F, Doyle R, Murphy DJ, Hunt SA (2008) Right ventricular function in cardiovascular disease, part II: pathophysiology, clinical importance, and management of right ventricular failure. Circulation 117:1717–1731. doi:10.1161/CIRCULATIONAHA.107.653584

    Article  PubMed  Google Scholar 

  23. Haddad F, Hunt SA, Rosenthal DN, Murphy DJ (2008) Right ventricular function in cardiovascular disease, part I: anatomy, physiology, aging, and functional assessment of the right ventricle. Circulation 117:1436–1448. doi:10.1161/CIRCULATIONAHA.107.653576

    Article  PubMed  Google Scholar 

  24. Handoko ML, de Man FS, Allaart CP, Paulus WJ, Westerhof N, Vonk-Noordegraaf A (2010) Perspectives on novel therapeutic strategies for right heart failure in pulmonary arterial hypertension: lessons from the left heart. Eur Respir Rev 19:72–82. doi:10.1183/09059180.00007109

    Article  CAS  PubMed  Google Scholar 

  25. Handoko ML, de Man FS, Happé CM, Schalij I, Musters RJP, Westerhof N, Postmus PE, Paulus WJ, van der Laarse WJ, Vonk-Noordegraaf A (2009) Opposite effects of training in rats with stable and progressive pulmonary hypertension. Circulation 120:42–49. doi:10.1161/CIRCULATIONAHA.108.829713

    Article  CAS  PubMed  Google Scholar 

  26. Heineke J, Molkentin JD (2006) Regulation of cardiac hypertrophy by intracellular signalling pathways. Nat Rev Mol Cell Biol 7:589–600. doi:10.1038/nrm1983

    Article  CAS  PubMed  Google Scholar 

  27. Hemnes AR, Brittain EL, Trammell AW, Fessel JP, Austin ED, Penner N, Maynard KB, Gleaves L, Talati M, Absi T, Disalvo T, West J (2013) Evidence for right ventricular lipotoxicity in heritable pulmonary arterial hypertension. Am J Respir Crit Care Med. doi:10.1164/rccm.201306-1086OC

    Google Scholar 

  28. Hoeper MM, Granton J (2011) Intensive care unit management of patients with severe pulmonary hypertension and right heart failure. Am J Respir Crit Care Med 184:1114–1124. doi:10.1164/rccm.201104-0662CI

    Article  CAS  PubMed  Google Scholar 

  29. Humbert M, Sitbon O, Chaouat A, Bertocchi M, Habib G, Gressin V, Yaïci A, Weitzenblum E, Cordier J-F, Chabot F, Dromer C, Pison C, Reynaud-Gaubert M, Haloun A, Laurent M, Cottin V, Degano B, Jaïs X, Montani D, Souza R, Simonneau G (2010) Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation 122:156–163. doi:10.1161/CIRCULATIONAHA.109.911818

    Article  PubMed  Google Scholar 

  30. Kapadia SR, Oral H, Lee J, Nakano M, Taffet GE, Mann DL (1997) Hemodynamic regulation of tumor necrosis factor-alpha gene and protein expression in adult feline myocardium. Circ Res 81:187–195. doi:10.1161/01.RES.81.2.187

    Article  CAS  PubMed  Google Scholar 

  31. Kentish JC, McCloskey DT, Layland J, Palmer S, Leiden JM, Martin AF, Solaro RJ (2001) Phosphorylation of troponin I by protein kinase A accelerates relaxation and crossbridge cycle kinetics in mouse ventricular muscle. Circ Res 88:1059–1065

    Article  CAS  PubMed  Google Scholar 

  32. Knöll R, Hoshijima M, Hoffman HM, Person V, Lorenzen-Schmidt I, Bang M-L, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork NJ, Omens JH, McCulloch AD, Kimura A, Gregorio CC, Poller W, Schaper J, Schultheiss HP, Chien KR (2002) The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell 111:943–955

    Article  PubMed  Google Scholar 

  33. Kramer MR, Valantine HA, Marshall SE, Starnes VA, Theodore J (1994) Recovery of the right ventricle after single-lung transplantation in pulmonary hypertension. Am J Cardiol 73:494–500

    Article  CAS  PubMed  Google Scholar 

  34. Kuehne T, Yilmaz S, Steendijk P, Moore P, Groenink M, Saaed M, Weber O, Higgins CB, Ewert P, Fleck E, Nagel E, Schulze-Neick I, Lange P (2004) Magnetic resonance imaging analysis of right ventricular pressure-volume loops: in vivo validation and clinical application in patients with pulmonary hypertension. Circulation 110:2010–2016. doi:10.1161/01.CIR.0000143138.02493.DD

    Article  PubMed  Google Scholar 

  35. Lee WW, Marinelli B, van der Laan AM, Sena BF, Gorbatov R, Leuschner F, Dutta P, Iwamoto Y, Ueno T, Begieneman MPV, Niessen HWM, Piek JJ, Vinegoni C, Pittet MJ, Swirski FK, Tawakol A, Di Carli M, Weissleder R, Nahrendorf M (2012) PET/MRI of inflammation in myocardial infarction. J Am Coll Cardiol 59:153–163. doi:10.1016/j.jacc.2011.08.066

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  36. Lohse MJ, Engelhardt S, Eschenhagen T (2003) What is the role of beta-adrenergic signaling in heart failure? Circ Res 93:896–906. doi:10.1161/01.RES.0000102042.83024.CA

    Article  CAS  PubMed  Google Scholar 

  37. Lowes BD, Minobe W, Abraham WT, Rizeq MN, Bohlmeyer TJ, Quaife RA, Roden RL, Dutcher DL, Robertson AD, Voelkel NF, Badesch DB, Groves BM, Gilbert EM, Bristow MR (1997) Changes in gene expression in the intact human heart. Downregulation of alpha-myosin heavy chain in hypertrophied, failing ventricular myocardium. J Clin Invest 100:2315–2324. doi:10.1172/JCI119770

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  38. De Man FS, Handoko ML, van Ballegoij JJM, Schalij I, Bogaards SJP, Postmus PE, van der Velden J, Westerhof N, Paulus WJ, Vonk-Noordegraaf A (2012) Bisoprolol delays progression towards right heart failure in experimental pulmonary hypertension. Circ Heart Fail 5:97–105. doi:10.1161/CIRCHEARTFAILURE.111.964494

    Article  PubMed  Google Scholar 

  39. De Man FS, Tu L, Handoko ML, Rain S, Ruiter G, François C, Schalij I, Dorfmüller P, Simonneau G, Fadel E, Perros F, Boonstra A, Postmus PE, van der Velden J, Vonk-Noordegraaf A, Humbert M, Eddahibi S, Guignabert C (2012) Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension. Am J Respir Crit Care Med 186:780–789. doi:10.1164/rccm.201203-0411OC

    Article  PubMed  Google Scholar 

  40. McCain ML, Parker KK (2011) Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function. Pflugers Arch 462:89–104. doi:10.1007/s00424-011-0951-4

    Article  CAS  PubMed  Google Scholar 

  41. Mielniczuk LM, Birnie D, Ziadi MC, deKemp RA, DaSilva JN, Burwash I, Tang AT, Davies RA, Haddad H, Guo A, Aung M, Williams K, Ukkonen H, Beanlands RSB (2011) Relation between right ventricular function and increased right ventricular [18F]fluorodeoxyglucose accumulation in patients with heart failure. Circ Cardiovasc Imaging 4:59–66. doi:10.1161/CIRCIMAGING.109.905984

    Article  PubMed  Google Scholar 

  42. Moulton MJ, Creswell LL, Ungacta FF, Downing SW, Szabó BA, Pasque MK (1996) Magnetic resonance imaging provides evidence for remodeling of the right ventricle after single-lung transplantation for pulmonary hypertension. Circulation 94:II312–II319

    CAS  PubMed  Google Scholar 

  43. Mudd JO, Kass DA (2008) Tackling heart failure in the twenty-first century. Nature 451:919–928. doi:10.1038/nature06798

    Article  CAS  PubMed  Google Scholar 

  44. Nagendran J, Sutendra G, Paterson I, Champion HC, Webster L, Chiu B, Haromy A, Rebeyka IM, Ross DB, Michelakis ED (2013) Endothelin axis is upregulated in human and rat right ventricular hypertrophy. Circ Res 112:347–354. doi:10.1161/CIRCRESAHA.111.300448

    Article  CAS  PubMed  Google Scholar 

  45. Oikawa M, Kagaya Y, Otani H, Sakuma M, Demachi J, Suzuki J, Takahashi T, Nawata J, Ido T, Watanabe J, Shirato K (2005) Increased [18F]fluorodeoxyglucose accumulation in right ventricular free wall in patients with pulmonary hypertension and the effect of epoprostenol. J Am Coll Cardiol 45:1849–1855. doi:10.1016/j.jacc.2005.02.065

    Article  CAS  PubMed  Google Scholar 

  46. Park A-M, Wong C-M, Jelinkova L, Liu L, Nagase H, Suzuki YJ (2010) Pulmonary hypertension-induced GATA4 activation in the right ventricle. Hypertension 56:1145–1151. doi:10.1161/HYPERTENSIONAHA.110.160515

    Article  CAS  PubMed  Google Scholar 

  47. Pasque MK, Trulock EP, Cooper JD, Triantafillou AN, Huddleston CB, Rosenbloom M, Sundaresan S, Cox JL, Patterson GA (1995) Single lung transplantation for pulmonary hypertension. Single institution experience in 34 patients. Circulation 92:2252–2258

    Article  CAS  PubMed  Google Scholar 

  48. Peacock AJ, Crawley S, McLure L, Blyth K, Vizza CD, Poscia R, Francone M, Iacucci I, Olschewski H, Kovacs G, Vonk Noordegraaf A, Marcus JT, van de Veerdonk MC, Oosterveer FPT (2013) Changes in right ventricular function measured by cardiac magnetic resonance imaging in patients receiving pulmonary arterial hypertension-targeted therapy: the EURO-MR study. Circ Cardiovasc Imaging. doi:10.1161/CIRCIMAGING.113.000629

    PubMed  Google Scholar 

  49. Peacock AJ, Vonk Noordegraaf A (2013) Cardiac magnetic resonance imaging in pulmonary arterial hypertension. Eur Respir Rev 22:526–534. doi:10.1183/09059180.00006313

    Article  PubMed  Google Scholar 

  50. Piao L, Fang Y-H, Parikh KS, Ryan JJ, D’Souza KM, Theccanat T, Toth PT, Pogoriler J, Paul J, Blaxall BC, Akhter SA, Archer SL (2012) GRK2-mediated inhibition of adrenergic and dopaminergic signaling in right ventricular hypertrophy: therapeutic implications in pulmonary hypertension. Circulation 126:2859–2869. doi:10.1161/CIRCULATIONAHA.112.109868

    Article  CAS  PubMed  Google Scholar 

  51. Radke MH, Peng J, Wu Y, McNabb M, Nelson OL, Granzier H, Gotthardt M (2007) Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy. Proc Natl Acad Sci U S A 104:3444–3449. doi:10.1073/pnas.0608543104

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  52. Rain S, Handoko ML, Trip P, Gan CT-J, Westerhof N, Stienen GJ, Paulus WJ, Ottenheijm CAC, Marcus JT, Dorfmüller P, Guignabert C, Humbert M, Macdonald P, Dos Remedios C, Postmus PE, Saripalli C, Hidalgo CG, Granzier HL, Vonk-Noordegraaf A, van der Velden J, de Man FS (2013) Right ventricular diastolic impairment in patients with pulmonary arterial hypertension. Circulation 128(2016–2025):1–10. doi:10.1161/CIRCULATIONAHA.113.001873

    Google Scholar 

  53. Rich S (2012) Right ventricular adaptation and maladaptation in chronic pulmonary arterial hypertension. Cardiol Clin 30:257–269. doi:10.1016/j.ccl.2012.03.004

    Article  PubMed  Google Scholar 

  54. Rondelet B, Dewachter C, Kerbaul F, Kang X, Fesler P, Brimioulle S, Naeije R, Dewachter L (2012) Prolonged overcirculation-induced pulmonary arterial hypertension as a cause of right ventricular failure. Eur Heart J 33:1017–1026. doi:10.1093/eurheartj/ehr111

    Article  CAS  PubMed  Google Scholar 

  55. Ruiter G, Ying Wong Y, de Man FS, Louis Handoko M, Jaspers RT, Postmus PE, Westerhof N, Niessen HWM, van der Laarse WJ, Vonk-Noordegraaf A (2013) Right ventricular oxygen supply parameters are decreased in human and experimental pulmonary hypertension. J Heart Lung Transplant 32:231–240. doi:10.1016/j.healun.2012.09.025

    Article  PubMed  Google Scholar 

  56. Sano M, Minamino T, Toko H, Miyauchi H, Orimo M, Qin Y, Akazawa H, Tateno K, Kayama Y, Harada M, Shimizu I, Asahara T, Hamada H, Tomita S, Molkentin JD, Zou Y, Komuro I (2007) p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload. Nature 446:444–448. doi:10.1038/nature05602

    Article  CAS  PubMed  Google Scholar 

  57. Schrier RW, Bansal S (2008) Pulmonary hypertension, right ventricular failure, and kidney: different from left ventricular failure? Clin J Am Soc Nephrol 3:1232–1237. doi:10.2215/CJN.01960408

    Article  PubMed  Google Scholar 

  58. Simon MA (2010) Right ventricular adaptation to pressure overload. Curr Opin Crit Care 16:237–243. doi:10.1097/MCC.0b013e3283382e58

    Article  PubMed  Google Scholar 

  59. Stenmark KR, Meyrick B, Galie N, Mooi WJ, McMurtry IF (2009) Animal models of pulmonary arterial hypertension: the hope for etiological discovery and pharmacological cure. Am J Physiol Lung Cell Mol Physiol 297:L1013–L1032. doi:10.1152/ajplung.00217.2009

    Article  CAS  PubMed  Google Scholar 

  60. Sun M, Chen M, Dawood F, Zurawska U, Li JY, Parker T, Kassiri Z, Kirshenbaum LA, Arnold M, Khokha R, Liu PP (2007) Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state. Circulation 115:1398–1407. doi:10.1161/CIRCULATIONAHA.106.643585

    Article  CAS  PubMed  Google Scholar 

  61. Sunagawa K, Yamada A, Senda Y, Kikuchi Y, Nakamura M, Shibahara T, Nose Y (1980) Estimation of the hydromotive source pressure from ejecting beats of the left ventricle. IEEE Trans Biomed Eng 27:299–305. doi:10.1109/TBME.1980.326737

    Article  CAS  PubMed  Google Scholar 

  62. Sutendra G, Dromparis P, Paulin R, Zervopoulos S, Haromy A, Nagendran J, Michelakis ED (2013) A metabolic remodeling in right ventricular hypertrophy is associated with decreased angiogenesis and a transition from a compensated to a decompensated state in pulmonary hypertension. J Mol Med (Berl) 91:1315–1327. doi:10.1007/s00109-013-1059-4

    Article  CAS  Google Scholar 

  63. Takeuchi M, Igarashi Y, Tomimoto S, Odake M, Hayashi T, Tsukamoto T, Hata K, Takaoka H, Fukuzaki H (1991) Single-beat estimation of the slope of the end-systolic pressure-volume relation in the human left ventricle. Circulation 83:202–212

    Article  CAS  PubMed  Google Scholar 

  64. Des Tombe AL, Van Beek-Harmsen BJ, Lee-De Groot MBE, Van Der Laarse WJ (2002) Calibrated histochemistry applied to oxygen supply and demand in hypertrophied rat myocardium. Microsc Res Tech 58:412–420. doi:10.1002/jemt.10153

    Article  CAS  PubMed  Google Scholar 

  65. Trip P, Kind T, van de Veerdonk MC, Marcus JT, de Man FS, Westerhof N, Vonk-Noordegraaf A (2013) Accurate assessment of load-independent right ventricular systolic function in patients with pulmonary hypertension. J Heart Lung Transplant 32:50–55. doi:10.1016/j.healun.2012.09.022

    Article  PubMed  Google Scholar 

  66. Van de Veerdonk MC, Kind T, Marcus JT, Mauritz G-J, Heymans MW, Bogaard H-J, Boonstra A, Marques KMJ, Westerhof N, Vonk-Noordegraaf A (2011) Progressive right ventricular dysfunction in patients with pulmonary arterial hypertension responding to therapy. J Am Coll Cardiol 58:2511–2519. doi:10.1016/j.jacc.2011.06.068

    Article  PubMed  Google Scholar 

  67. Voelkel NF, Quaife RA, Leinwand LA, Barst RJ, McGoon MD, Meldrum DR, Dupuis J, Long CS, Rubin LJ, Smart FW, Suzuki YJ, Gladwin M, Denholm EM, Gail DB, National Heart, Lung, and Blood Institute Working Group on Cellular and Molecular Mechanisms of Right Heart Failure (2006) Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure. Circulation 114:1883–1891. doi:10.1161/CIRCULATIONAHA.106.632208

    Article  PubMed  Google Scholar 

  68. Vonk Noordegraaf A, Galiè N (2011) The role of the right ventricle in pulmonary arterial hypertension. Eur Respir Rev 20:243–253. doi:10.1183/09059180.00006511

    Article  CAS  PubMed  Google Scholar 

  69. Vonk-Noordegraaf A, Haddad F, Chin KM, Forfia PR, Kawut SM, Lumens J, Naeije R, Newman J, Oudiz RJ, Provencher S, Torbicki A, Voelkel NF, Hassoun PM (2013) Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology. J Am Coll Cardiol 62:D22–D33. doi:10.1016/j.jacc.2013.10.027

    Article  PubMed  Google Scholar 

  70. Walker LA, Walker JS, Glazier A, Brown DR, Stenmark KR, Buttrick PM (2011) Biochemical and myofilament responses of the right ventricle to severe pulmonary hypertension. Am J Physiol Heart Circ Physiol 301:H832–H840. doi:10.1152/ajpheart.00249.2011

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  71. Westerhof N, Stergiopulos N, Noble MIM (2005) Snapshots of hemodynamics. An aid for clinical research and graduate education, 2nd edn. Springer, New York

  72. Van Wolferen SA, Marcus JT, Boonstra A, Marques KMJ, Bronzwaer JGF, Spreeuwenberg MD, Postmus PE, Vonk-Noordegraaf A (2007) Prognostic value of right ventricular mass, volume, and function in idiopathic pulmonary arterial hypertension. Eur Heart J 28:1250–1257. doi:10.1093/eurheartj/ehl477

    Article  PubMed  Google Scholar 

  73. Wong YY, Handoko ML, Mouchaers KTB, de Man FS, Vonk-Noordegraaf A, van der Laarse WJ (2010) Reduced mechanical efficiency of rat papillary muscle related to degree of hypertrophy of cardiomyocytes. Am J Physiol Heart Circ Physiol 298:H1190–H1197. doi:10.1152/ajpheart.00773.2009

    Article  CAS  PubMed  Google Scholar 

  74. Wong YY, Ruiter G, Lubberink M, Raijmakers PG, Knaapen P, Marcus JT, Boonstra A, Lammertsma AA, Westerhof N, van der Laarse WJ, Vonk-Noordegraaf A (2011) Right ventricular failure in idiopathic pulmonary arterial hypertension is associated with inefficient myocardial oxygen utilization. Circ Heart Fail 4:700–706. doi:10.1161/CIRCHEARTFAILURE.111.962381

    Article  CAS  PubMed  Google Scholar 

  75. Yadid M, Sela G, Amiad Pavlov D, Landesberg A (2011) Adaptive control of cardiac contraction to changes in loading: from theory of sarcomere dynamics to whole-heart function. Pflugers Arch Eur J Physiol 462:49–60. doi:10.1007/s00424-011-0966-x

    Article  CAS  Google Scholar 

  76. Yamasaki R, Wu Y, McNabb M, Greaser M, Labeit S, Granzier H (2002) Protein kinase A phosphorylates titin’s cardiac-specific N2B domain and reduces passive tension in rat cardiac myocytes. Circ Res 90:1181–1188

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Physiology, VU University Medical Center/Institute for Cardiovascular Research (ICaR-VU), Amsterdam, The Netherlands

    S. Rain, M. L. Handoko, J. van der Velden & F. S. de Man

  2. Department of Pulmonology, VU University Medical Center/Institute for Cardiovascular Research (ICaR-VU), Amsterdam, The Netherlands

    S. Rain, A. Vonk Noordegraaf, H. J. Bogaard & F. S. de Man

  3. Department of Cardiology, VU University Medical Center/Institute for Cardiovascular Research (ICaR-VU), Amsterdam, The Netherlands

    M. L. Handoko

  4. ICIN, Netherlands Heart Institute, Utrecht, The Netherlands

    J. van der Velden

  5. Department of Pulmonology, VU University Medical Center, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands

    F. S. de Man

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Correspondence to F. S. de Man.

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Rain, S., Handoko, M.L., Vonk Noordegraaf, A. et al. Pressure-overload-induced right heart failure. Pflugers Arch - Eur J Physiol 466, 1055–1063 (2014). https://doi.org/10.1007/s00424-014-1450-1

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  • DOI: https://doi.org/10.1007/s00424-014-1450-1

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