Skip to main content
SpringerLink
Log in

Plasmodium falciparum: in vitro growth inhibition by febrile temperatures

  • Original Paper
  • Published:
Parasitology Research Aims and scope Submit manuscript

Abstract.

Febrile episodes are the hallmark of malarial infection. We determined the inhibitory effect of febrile temperatures on the in vitro growth of Plasmodium falciparum. Parasites were cultured at various temperatures between 37 °C and 40 °C for 4 days. A logistic decrease in parasitaemia as a function of temperature was observed for continuous cultures. Incubation of synchronized cultures for different lengths of time during the parasite cycle showed a strong increase of growth inhibition with the maturing of parasites. Febrile temperatures inhibit parasite growth and long, high fevers during malaria may be beneficial for parasite clearance.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Wilhelmstrasse 27, 72074 Tübingen, Germany, , , , ,

    ,   & 

  2. Department of Medical Biometry, Westbahnhofstrasse 55, University of Tübingen, 72070 Tübingen, Germany, , , , ,

Authors
  1. View author publications

    You can also search for this author in PubMed Google Scholar

  2. View author publications

    You can also search for this author in PubMed Google Scholar

  3. View author publications

    You can also search for this author in PubMed Google Scholar

  4. View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Electronic Publication

Rights and permissions

Reprints and permissions

About this article

Cite this article

, ., , ., , . et al. Plasmodium falciparum: in vitro growth inhibition by febrile temperatures. Parasitol Res 87, 553–555 (2001). https://doi.org/10.1007/s004360100374

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s004360100374

Keywords

Search

Navigation