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Fibrillin I gene polymorphism is associated with tall stature of normal individuals

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Abstract

In order to test the hypothesis that polymorphisms of the Marfan syndrome gene (FBN1) might affect the stature (height) of normal individuals, we genotyped three exonic SNPs on 428 males, 219 with tall stature (>2 SD) and 209 with normal stature (within ±1 SD). One of the SNPs, rs8033037, in exon 15 showed a significant correlation (P = 0.0061) with the adult height, suggesting that FBN1 is one of the ‘stature genes’ of normal individuals.

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Acknowledgments

The study protocol was approved by the Institutional Review Board of Kyoto University Hospital. This work was supported in part by the following grants. Novo Nordisk Growth Award and a research grant from the Foundation of Growth Science (2004, no. 27).

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Authors and Affiliations

  1. Department of Pediatrics, Kyoto University Hospital, 54 Shogoin Sakyo, Kyoto, 606-8507, Japan

    Mitsukazu Mamada, Tohru Yorifuji, Junko Yorifuji, Keiji Kurokawa, Masahiko Kawai, Toru Momoi & Tatsutoshi Nakahata

  2. Department of Pediatrics, Japanese Red Cross Society Wakayama Medical Center, Wakayama, Japan

    Toru Momoi

Authors
  1. Mitsukazu Mamada
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  2. Tohru Yorifuji
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  3. Junko Yorifuji
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  4. Keiji Kurokawa
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  5. Masahiko Kawai
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  6. Toru Momoi
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  7. Tatsutoshi Nakahata
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Corresponding author

Correspondence to Tohru Yorifuji.

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Mamada, M., Yorifuji, T., Yorifuji, J. et al. Fibrillin I gene polymorphism is associated with tall stature of normal individuals. Hum Genet 120, 733–735 (2007). https://doi.org/10.1007/s00439-006-0263-5

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  • DOI: https://doi.org/10.1007/s00439-006-0263-5

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