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Positive association between OLIG2 and schizophrenia in the Chinese Han population

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Abstract

A recent study reported that OLIG2 had a significant association with schizophrenia in the UK population. We genotyped three variants scattered among the genomic region of OLIG2, namely rs1005573, rs762178 and rs1059004 in a sample consisting of 329 schizophrenia patients and 288 controls. The results provide further evidence that the SNP rs762178 in OLIG2 seems to be a potential candidate in altering risk for schizophrenia in the Chinese Han population and worthy of further replication and functional study.

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Acknowledgments

We are deeply grateful to all the participants as well as to the psychiatrists and mental health workers working on this project. The study was supported by the National 973 and 863 programs and the Key grant project of the Chinese Ministry of Education (No. 10414), PRC.

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Authors and Affiliations

  1. Bio-X Center, Shanghai Jiao Tong University, PO Box 501, Haoran Building, 1954 Huashan Road, Shanghai, 200030, People’s Republic of China

    Ke Huang, Wei Tang, Ruqi Tang, Zhao Xu, Zhangdong He, Zhiqiang Li, Xingwang Li, Guang He, Lin He & YongYong Shi

  2. Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China

    Ke Huang, Wei Tang, Ruqi Tang, Zhao Xu, Zhangdong He, Zhiqiang Li, Xingwang Li, Guang He, Lin He & YongYong Shi

  3. Shanghai Institute of Mental Health, Shanghai, 200030, China

    Yifeng Xu & Guoying Feng

Authors
  1. Ke Huang
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  2. Wei Tang
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  3. Ruqi Tang
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  4. Zhao Xu
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  5. Zhangdong He
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  6. Zhiqiang Li
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  7. Yifeng Xu
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  8. Xingwang Li
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  9. Guang He
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  10. Guoying Feng
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  11. Lin He
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  12. YongYong Shi
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Corresponding authors

Correspondence to Lin He or YongYong Shi.

Additional information

Ke Huang, Wei Tang and Yongyong Shi contributed equally to this work.

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Huang, K., Tang, W., Tang, R. et al. Positive association between OLIG2 and schizophrenia in the Chinese Han population. Hum Genet 122, 659–660 (2008). https://doi.org/10.1007/s00439-007-0434-z

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  • DOI: https://doi.org/10.1007/s00439-007-0434-z

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