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ATG16L1 T300A polymorphism and Crohn’s disease susceptibility: evidence from 13,022 cases and 17,532 controls

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Abstract

Many studies have reported the association between the autophagy-related 16-like 1 gene (ATG16L1) T300A polymorphism (rs2241880) and Crohn’s disease (CD) susceptibility, but the results were inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 24 studies including 13,022 cases and 17,532 controls were included in this meta-analysis. Logistic regression analysis indicated that the ATG16L1 T300A polymorphism was associated with CD risk in Caucasians (P < 0.01). The pooled estimations of OR1 (GG vs. AA) and OR2 (GA vs. AA) in Caucasian studies by Bayesian meta-analysis method was [1.87, 95% confidence interval (CI) 1.69–2.05] and (1.39, 95% CI 1.27–1.51), respectively. The mode of heritance of the G allele was most likely to be co-dominant in Caucasians. However, no significant association was found in Asians. This meta-analysis suggests that the G allele of ATG16L1 T300A is a low-penetrant gene for developing CD in Caucasians.

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Authors and Affiliations

  1. Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning, China

    Hai-Feng Zhang, Wa-Li Zhu, Li-Guang Zhu, Yan Wang & Lei Lei

  2. Department of Medical Oncology, Cancer Hospital, Shanghai Medical College, Fudan University, Shanghai, China

    Li-Xin Qiu

  3. Department of Laboratory Medicine, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China

    Yu Chen

  4. Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China

    Chen Mao

  5. Department of Infection and Liver Diseases, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China

    Ming-Hua Zheng

  6. Department of Gastroenterology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China

    Jian Shi

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  1. Hai-Feng Zhang
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  2. Li-Xin Qiu
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  3. Yu Chen
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  4. Wa-Li Zhu
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  5. Chen Mao
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  6. Li-Guang Zhu
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  7. Ming-Hua Zheng
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  8. Yan Wang
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  9. Lei Lei
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  10. Jian Shi
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Corresponding authors

Correspondence to Li-Guang Zhu or Jian Shi.

Additional information

H.-F. Zhang, L.-X. Qiu and Y. Chen have contributed equally to this work and should be considered as co-first authors.

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Table 1 Main characteristics of the included studies (DOC 89 kb)

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Zhang, HF., Qiu, LX., Chen, Y. et al. ATG16L1 T300A polymorphism and Crohn’s disease susceptibility: evidence from 13,022 cases and 17,532 controls. Hum Genet 125, 627–631 (2009). https://doi.org/10.1007/s00439-009-0660-7

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