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Proinflammatory cytokines and procalcitonin in children with acute pyelonephritis

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Abstract

This prospective study, performed in 76 children with a urinary tract infection (UTI), evaluates the diagnostic value of procalcitonin (PCT) and proinflammatory cytokines (IL-1β, IL-6 and TNF-α) in children with acute pyelonephritis documented by dimercaptosuccinic acid scintigraphy (DMSA). Renal parenchymal involvement was assessed by 99m Tc-DMSA scintigraphy within 7 days of admission. The diagnosis of acute pyelonephritis was confirmed only in patients with reversible lesions on scintigraphy. According to DMSA scan results, patients were divided into two groups, lower UTI or acute pyelonephritis. In acute pyelonephritis, serum PCT level was found to be significantly higher than it is in the lower UTI (p <0.001). Also, significantly higher serum proinflammatory cytokines (IL-1β, IL-6 and TNF-α) levels were detected in those with acute pyelonephritis than those with lower UTI (p <0.001). We conclude that both serum PCT and proinflammatory cytokine levels may be used as accurate markers for diagnosis of acute pyelonephritis.

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Authors and Affiliations

  1. Department of Pediatrics, Firat University Faculty of Medicine, Elazig, Turkey

    Metin Kaya Gürgöze, Saadet Akarsu, Erdal Yilmaz, Zehra Akça & A. Denizmen Aygün

  2. Department of Immunology, Firat University Faculty of Medicine, Elazig, Turkey

    Ahmet Gödekmerdan

  3. Department of Nuclear Medicine, Firat University Faculty of Medicine, Elazig, Turkey

    Ismail Çiftçi

  4. Firat Universitesi Tıp Fakultesi, Cocuk Sağlığı ve Hastalıkları, Anabilim Dalı, 23119, Elazig, Turkey

    Metin Kaya Gürgöze

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  1. Metin Kaya Gürgöze
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  2. Saadet Akarsu
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  3. Erdal Yilmaz
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  4. Ahmet Gödekmerdan
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  5. Zehra Akça
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  6. Ismail Çiftçi
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  7. A. Denizmen Aygün
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Correspondence to Metin Kaya Gürgöze.

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Gürgöze, M.K., Akarsu, S., Yilmaz, E. et al. Proinflammatory cytokines and procalcitonin in children with acute pyelonephritis. Pediatr Nephrol 20, 1445–1448 (2005). https://doi.org/10.1007/s00467-005-1941-6

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  • DOI: https://doi.org/10.1007/s00467-005-1941-6

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