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Regulation of apoptosis by protein S-nitrosylation

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Summary.

S-nitrosylation/denitrosylation of critical cysteine residues on proteins serves as a redox switch that regulates the function of a wide array of proteins. A key signaling pathway that is regulated by S-nitrosylation is apoptotic cell death. Here we will review the proteins in apoptotic pathways that are known to be S-nitrosylated by endogenous NO production. The targets and functional consequences of S-nitrosylation during apoptosis are multifaceted, allowing cells to fine tune their response to apoptotic signals.

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Authors and Affiliations

  1. Department of Medicine, University of Massachusetts Medical School, Worcester, MA, U.S.A.

    J. B. Mannick

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Mannick, J. Regulation of apoptosis by protein S-nitrosylation. Amino Acids 32, 523–526 (2007). https://doi.org/10.1007/s00726-006-0427-6

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  • DOI: https://doi.org/10.1007/s00726-006-0427-6

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