Abstract
Creatine monohydrate (Cr), the most diffuse supplement in the sports industry, is receiving greater attention because of its beneficial effects in a wide number of human degenerative diseases and conditions. These effects can be barely explained on the basis of the sole ergogenic role of the Cr/CrP system. Indeed, a wide number of research articles indicate that Cr is capable of exerting multiple, non-energy related, effects on diverse and relevant cellular targets. Among these effects, the antioxidant activity of Cr emerges as an additional mechanism which is likely to play a supportive role in the Cr-cytoprotection paradigm.
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Sestili, P., Martinelli, C., Colombo, E. et al. Creatine as an antioxidant. Amino Acids 40, 1385–1396 (2011). https://doi.org/10.1007/s00726-011-0875-5
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DOI: https://doi.org/10.1007/s00726-011-0875-5