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Creatine-induced glucose uptake in type 2 diabetes: a role for AMPK-α?

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Abstract

This study focused on understanding the signaling mechanisms leading to GLUT-4 translocation and increased skeletal-muscle glucose uptake that follow creatine (Cr) supplementation in type 2 diabetes (n = 10). AMPK-α protein content presented a tendency to be higher (p = 0.06) after Cr supplementation (5 g/d for 12w). The changes in AMPK-α protein content significantly related (p < 0.001) to the changes in GLUT-4 translocation (r = 0.78) and Hb1Ac levels (r = −0.68), suggesting that AMPK signaling may be implicated in the effects of supplementation on glucose uptake in type 2 diabetes.

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Acknowledgments

The authors are grateful to Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP). The authors also thank Probiotica® for providing the dietary supplements.

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The authors declare no conflict of interests.

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Authors and Affiliations

  1. School of Physical Education and Sports, University of Sao Paulo, Av Mello de Moraes, 65–Butantã, Sao Paulo, SP, 05508-030, Brazil

    Christiano Robles Rodrigues Alves, Júlio César Ferreira, Antonio Herbert Lancha Jr. & Bruno Gualano

  2. Biosciences Institute, University of Sao Paulo, Sao Paulo, Brazil

    Mário Alves de Siqueira-Filho & Carla Roberta Carvalho

Authors
  1. Christiano Robles Rodrigues Alves
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  2. Júlio César Ferreira
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  3. Mário Alves de Siqueira-Filho
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  4. Carla Roberta Carvalho
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  5. Antonio Herbert Lancha Jr.
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  6. Bruno Gualano
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Correspondence to Bruno Gualano.

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Alves, C.R.R., Ferreira, J.C., de Siqueira-Filho, M.A. et al. Creatine-induced glucose uptake in type 2 diabetes: a role for AMPK-α?. Amino Acids 43, 1803–1807 (2012). https://doi.org/10.1007/s00726-012-1246-6

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  • DOI: https://doi.org/10.1007/s00726-012-1246-6

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