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Alterations of amino acid metabolism in osteoarthritis: its implications for nutrition and health

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Abstract

Osteoarthritis (OA) is a common form of arthritis in humans. It has long been regarded as a non-inflammatory disease, but a degree of inflammation is now recognized as being a vital inducer of subpopulation of OA. Besides inflammation, the establishment and development of OA are associated with alterations in metabolism and profiles of amino acids (AA), including glutamate- and arginine-family AA as well as their related metabolites (e.g., creatinine, hydroxyproline, γ-aminobutyrate, dimethylarginines and homoarginine). Functional AA (e.g., glutamine, arginine, glutamate, glycine, proline, and tryptophan) have various benefits (i.e., anti-inflammation and anti-oxidation) in treatment of inflammation-associated diseases, including OA. Thus, these AA have potential as immunomodulatory nutrients for patients with inflammation-induced OA.

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Abbreviations

AA:

Amino acid(s)

HSP:

Heat shock proteins

IκB:

Inhibitor of κBs

IL:

Interleukin

iNOS:

Inducible nitric oxide synthase

MMP:

Matrix metalloproteinase

NF-κB:

Nuclear factor-κB

NO:

Nitric oxide

OA:

Osteoarthritis

PPAR γ:

Peroxisome proliferator-activated receptor-γ

SAM:

S-Adenosylmethionine

TNF-α:

Tumor necrosis factor-α

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 81201420, 81272034, 81402224, 81472130), the Provincial Science Foundation of Hunan (No. 14JJ3032, No. 2015JJ3139), the Development and Reform Commission of Hunan Province ([2013]1199, [2014]658-8), the Science and Technology Office of Hunan Province (2012FJ6001,2013SK2018),the Science and Technology Office of Changsha City (K1203040-31), the Health and Family Planning Commission of Hunan Province (B2014-12), the Administration of Traditional Chinese Medicine of Hunan Province (No.2015115), and Texas A&M AgriLife Research (H-8200).

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Authors and Affiliations

  1. Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, 410078, Hunan, China

    Yusheng Li, Wenfeng Xiao, Wei Luo, Chao Zeng, Zhenhan Deng & Guanghua Lei

  2. Laboratory of Animal Nutrition and Health and Key Laboratory of Agro-Ecology, Institute of Subtropical Agriculture, The Chinese Academy of Sciences, Changsha, 410125, Hunan, China

    Wenkai Ren

  3. Department of Animal Science, Texas A&M University, 2471 TAMU, College Station, TX, 77843-2471, USA

    Guoyao Wu

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  1. Yusheng Li
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Correspondence to Guanghua Lei.

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Li, Y., Xiao, W., Luo, W. et al. Alterations of amino acid metabolism in osteoarthritis: its implications for nutrition and health. Amino Acids 48, 907–914 (2016). https://doi.org/10.1007/s00726-015-2168-x

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  • DOI: https://doi.org/10.1007/s00726-015-2168-x

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