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The role of methionine on metabolism, oxidative stress, and diseases

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Abstract

Methionine is an aliphatic, sulfur-containing, essential amino acid, and a precursor of succinyl-CoA, homocysteine, cysteine, creatine, and carnitine. Recent research has demonstrated that methionine can regulate metabolic processes, the innate immune system, and digestive functioning in mammals. It also intervenes in lipid metabolism, activation of endogenous antioxidant enzymes such as methionine sulfoxide reductase A, and the biosynthesis of glutathione to counteract oxidative stress. In addition, methionine restriction prevents altered methionine/transmethylation metabolism, thereby decreasing DNA damage and carcinogenic processes and possibly preventing arterial, neuropsychiatric, and neurodegenerative diseases. This review focuses on the role of methionine in metabolism, oxidative stress, and related diseases.

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Acknowledgements

This research was supported by National Natural Science Foundation of China (No. 31772642), International Partnership Program of Chinese Academy of Sciences (161343KYSB20160008), National Key Research and Development Program of China (2016YFD0500504), and Chinese Academy of Sciences visiting professorship for senior international scientists Grant no. 2016VBB007.

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  1. Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, Hunan, China

    Yordan Martínez, Xue Li, Gang Liu, Peng Bin, Wenxin Yan, Chien-An Andy Hu, Wenkai Ren & Yulong Yin

  2. National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125, Hunan, China

    Yordan Martínez, Xue Li, Gang Liu, Peng Bin, Wenxin Yan, Chien-An Andy Hu, Wenkai Ren & Yulong Yin

  3. Department of Animal Production, Faculty of Veterinary Medicine, Agricultural University of Havana, 32700, San José de Las Lajas, Mayabeque, Cuba

    Yordan Martínez

  4. Faculty of Natural Sciences, University of Queretaro, Querétaro, Mexico

    Dairon Más

  5. Department of Management and Feeding of Monogastric Animals, Institute of Animal Science, 32700, San José de Las Lajas, Mayabeque, Cuba

    Manuel Valdivié

  6. Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, MSC08 4670, Fitz 258, Albuquerque, NM, 87131, USA

    Chien-An Andy Hu

  7. Animal Nutrition and Human Health Laboratory, School of Life Sciences, Hunan Normal University, Changsha, 410081, Hunan, China

    Chien-An Andy Hu & Yulong Yin

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  1. Yordan Martínez
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  2. Xue Li
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Handling Editors: C.-A.A. Hu, Y. Yin, Y. Hou, G. Wu, Y. Teng.

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Martínez, Y., Li, X., Liu, G. et al. The role of methionine on metabolism, oxidative stress, and diseases. Amino Acids 49, 2091–2098 (2017). https://doi.org/10.1007/s00726-017-2494-2

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