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In situ remineralizing effect of fluoride varnishes containing sodium trimetaphosphate

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Abstract

Objective

This study analyzed the effects of a fluoride (F) varnish supplemented with sodium trimetaphosphate (TMP) on the remineralization of caries-like lesions in situ.

Materials and methods

Twelve subjects used palatal devices with demineralized enamel discs for 3 days, following a double-blind, crossover protocol. Test groups included placebo (no F or TMP), 5 % NaF and 5 % NaF/5 % TMP varnishes. The percentage of surface hardness recovery (%SHR) and cross-sectional hardness (ΔKHN) were determined.

Results

Significant differences were observed among all varnishes regarding %SHR and ΔKHN. The highest %SHR and the lowest ΔKHN were seen for the 5 % NaF/5 % TMP varnish, followed by 5 % NaF and placebo.

Conclusion

The remineralizing effect of a 5 % NaF varnish is significantly enhanced when associated with TMP.

Clinical relevance

The reduction in the subsurface lesion area of enamel treated with the TMP-containing varnish implies that cavities would take longer to develop or might not develop at all depending on individual factors, resulting in lower net caries increments at individual and population levels.

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Acknowledgments

This paper is based on a thesis submitted by the first author to Araçatuba Dental School, São Paulo State University (Brazil), in partial fulfillment of the requirements for a PhD degree in Dental Science (Pediatric Dentistry). We also thank to CAPES for the concession of a scholarship to the first author and to SS White Dental Products for the manufacturing of the varnishes.

Compliance with ethical standards

ᅟ

Funding

This study was funded by CAPES (Coordination for the Improvement of Higher Education—Brazil), through a scholarship granted to the first author.

Conflict of interest

Authors MM Manarelli, ACB Delbem, TDB Binhardi and JP Pessan declare they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Authors and Affiliations

  1. Department of Pediatric Dentistry and Public Health, Araçatuba Dental School, Univ. Estadual Paulista (UNESP), Rua Jose Bonifacio 1193, 16015-050, Araçatuba, SP, Brazil

    M. M. Manarelli, A. C. B. Delbem, T. D. R. Binhardi & J. P. Pessan

Authors
  1. M. M. Manarelli
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  2. A. C. B. Delbem
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  3. T. D. R. Binhardi
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  4. J. P. Pessan
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Corresponding author

Correspondence to J. P. Pessan.

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Manarelli, M.M., Delbem, A.C.B., Binhardi, T.D.R. et al. In situ remineralizing effect of fluoride varnishes containing sodium trimetaphosphate. Clin Oral Invest 19, 2141–2146 (2015). https://doi.org/10.1007/s00784-015-1492-6

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  • DOI: https://doi.org/10.1007/s00784-015-1492-6

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