Abstract
Malignant astrocytomas are characterized by diffusely infiltrating nature, and the abnormality of p53 is a cytogenetic hallmark of astrocytic tumors. To elucidate the relationship between p53 abnormality and invasiveness of the tumors, we studied mutation and protein expression of p53 in 48 consecutive patients with malignant astrocytoma (14 anaplastic astrocytomas and 34 glioblastoma multiformes). The tumors were classified into three categories according to the features of magnetic resonance imaging, and 5, 7, and 36 tumors were classified into diffuse, multiple, and single type, respectively. We then examined how these tumor types correlate with MIB-1 staining index, TP53 gene mutation, and p53 protein expression. We found that p53 immunopositivity or TP53 mutation was frequently observed in diffuse and multiple types. These abnormalities of p53 were also associated with high MIB-1 staining index and strong expression of vascular endothelial growth factor. Furthermore, diffuse- and multiple-type tumors were significantly correlated with poor progression-free survival, whereas only multiple-type tumors were significantly correlated with poor overall survival. As diffuse and multiple features on imaging modalities represent invasive characteristics of the tumors, p53 abnormalities may affect the invasive and aggressive nature of malignant astrocytomas.
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Louis DN, Ohgaki H, Wiestler OD, et al (eds) Tumours of the central nervous system. World Health Organization classification of tumours. IARC, Lyon, pp 25–52
Stupp R, Mason WP, van den Bent MJ, et al (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352:987–996
Momota H, Shih AH, Edgar MA, et al (2008) c-Myc and beta-catenin cooperate with loss of p53 to generate multiple members of the primitive neuroectodermal tumor family in mice. Oncogene 27:4392–4401
Lamborn KR, Chang SM, Prados MD (2004) Prognostic factors for survival of patients with glioblastoma: recursive partitioning analysis. Neurooncology 6:227–235
Barnard RO, Geddes JF (1987) The incidence of multifocal cerebral gliomas. A histologic study of large hemisphere sections. Cancer (Phila) 60:1519–1531
Hefti M, von Campe G, Schneider C, et al (2010) Multicentric tumor manifestations of high grade gliomas: independent proliferation or hallmark of extensive disease? Cen Eur Neurosurg 71:20–25
Lim DA, Cha S, Mayo MC, et al (2007) Relationship of glioblastoma multiforme to neural stem cell regions predicts invasive and multifocal tumor phenotype. Neurooncology 9:424–429
Muller PA, Caswell PT, Doyle B, et al (2009) Mutant p53 drives invasion by promoting integrin recycling. Cell 139:1327–1341
Lim SO, Kim H, Jung G (2010) p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma. FEBS Lett 584:2231–2236
Miyagami M, Katayama Y (2005) Angiogenesis of glioma: evaluation of ultrastructural characteristics of microvessels and tubular bodies (Weibel-Palade) in endothelial cells and immunohistochemical findings with VEGF and p53 protein. Med Mol Morphol 38:36–42
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Momota, H., Narita, Y., Matsushita, Y. et al. p53 abnormality and tumor invasion in patients with malignant astrocytoma. Brain Tumor Pathol 27, 95–101 (2010). https://doi.org/10.1007/s10014-010-0272-x
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DOI: https://doi.org/10.1007/s10014-010-0272-x