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Spindle cell oncocytoma of the adenohypophysis

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Abstract

Spindle cell oncocytoma of the adenohypophysis (SCO) is defined as spindle to epithelioid cells with oncocytic appearance presenting in the adenohypophysis. In contrast to pituitary adenomas, the SCO does not show immunoreactivity for neuroendocrine markers and pituitary hormones but co-expressed vimentin, S-100 protein, epithelial membrane antigen (EMA), and antimitochondrial antibody MU213-UC clone 131-1. We describe an SCO in an adult, a 42-year-old woman whose magnetic resonance (MR) images documented an intrasellar lesion located in the hypophysis. Histopathological examination showed a tumor composed predominantly of spindle cells. Immunohistochemical studies showed positivity for vimentin, S10, EMA, and antimitochondrial antibody MU213-UC clone 131. Cytokeratin (CK) (AE1/AE3), glial fibrillary acidic protein (GFAP), chromogranin, synaptophysin, PGP9.5, CD57, desmin, D2-40, smooth muscle actin (SMA), Bcl-2, progesterone receptor, and CD34 were negative. Neuropeptides were negative. With electron microscopy, the neoplastic cells appear filled with mitochondria, well-formed desmosomes, but lacked secretory granules. SPO is a rare non-endocrine neoplasm of the adenohypophysis with benign biological behavior corresponding to WHO grade I.

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Authors and Affiliations

  1. Grupo de Patología del Instituto Nacional de Cancerología INC, Bogotá, Colombia

    Alfredo Ernesto Romero-Rojas, Sandra Isabel Chinchilla-Olaya & Ligia Inés Restrepo Escobar

  2. Grupo Patología Estructural Funcional y Clínica de la Universidad Industrial de Santander PATUIS, Bucaramanga, Colombia

    Mario Alexander Melo-Uribe & Paula Alejandra Barajas-Solano

  3. Hospital San Jose, Bogotá, Colombia

    Diana Marcela Hernandez-Walteros

  4. Calle 152B #58C-49 Interior 5 Apartment 503, Bogotá, Colombia

    Alfredo Ernesto Romero-Rojas

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  1. Alfredo Ernesto Romero-Rojas
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  2. Mario Alexander Melo-Uribe
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  3. Paula Alejandra Barajas-Solano
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  4. Sandra Isabel Chinchilla-Olaya
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  5. Ligia Inés Restrepo Escobar
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  6. Diana Marcela Hernandez-Walteros
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Correspondence to Alfredo Ernesto Romero-Rojas.

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Romero-Rojas, A.E., Melo-Uribe, M.A., Barajas-Solano, P.A. et al. Spindle cell oncocytoma of the adenohypophysis. Brain Tumor Pathol 28, 359–364 (2011). https://doi.org/10.1007/s10014-011-0051-3

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  • DOI: https://doi.org/10.1007/s10014-011-0051-3

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