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Primary myxopapillary ependymoma of the fourth ventricle with cartilaginous metaplasia: a case report and review of the literature

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Abstract

Myxopapillary ependymoma (MPE), which is a benign histological subtype of ependymoma, is found predominantly in the cauda equina region. It occurs rarely in the brain and mostly as a metastatic deposit from a spinal lesion. The occurrence of primary intracranial MPE is exceptional, with only 11 cases reported to date. We report an additional case of intracranial MPE, which is the third reported case in the fourth ventricle. The tumor manifested in a 50-year-old lady, who presented with features of raised intracranial pressure. A gross total resection of the tumor was achieved. Histologically, the tumor had characteristic features of MPE with focal metaplastic cartilaginous deposit. On further evaluation, there was no evidence of a primary tumor in the spinal cord. Intracranial MPE needs further evaluation by craniospinal MRI to exclude an unrecognized primary in the spinal region, which could warrant surgical attention.

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Acknowledgments

The authors acknowledge the technical assistance of Mr. K. Prem and Mr. K. Manjunath of Department of Neuropathology, National Institute of Mental Health and Neurosciences.

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Authors and Affiliations

  1. Department of Neuropathology, National Institute of Mental Health and Neurosciences, Hosur Road, Bangalore, Karnataka, 560 029, India

    Shrijeet Chakraborti, Aparna Govindan & Vani Santosh

  2. Department of Neurosurgery, Government Medical College, Calicut, Kerala, 673 008, India

    Jacob P. Alapatt & M. Radhakrishnan

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  1. Shrijeet Chakraborti
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  2. Aparna Govindan
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  3. Jacob P. Alapatt
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Correspondence to Shrijeet Chakraborti.

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Chakraborti, S., Govindan, A., Alapatt, J.P. et al. Primary myxopapillary ependymoma of the fourth ventricle with cartilaginous metaplasia: a case report and review of the literature. Brain Tumor Pathol 29, 25–30 (2012). https://doi.org/10.1007/s10014-011-0059-8

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  • DOI: https://doi.org/10.1007/s10014-011-0059-8

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