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Multinodular and vacuolating neuronal tumor of the cerebrum

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Abstract

Multinodular and vacuolating neuronal tumors of the cerebrum (MVNT) are superficial neuronal tumors in adults that were first documented in 2013. Herein, we report a case of MNVT involving a 37-year-old man who presented with an epileptogenic, superficial solid lesion in the left parietal lobe. Histomorphology of the resected specimen was characterized by nodular lesions with vacuolation. Nodules comprised irregular proliferation of neuronal cells, which ranged from ganglion-like forms to those with indistinct lineage. Immunohistochemical analysis showed that the lesional cells stained positively for HuC/HuD, synaptophysin, and Olig2, and negatively for NeuN, neurofilament, chromogranin A, GFAP, CD34, IDH1R132H, and BRAFV600E. Eighteen months following surgery, the patient is well and without neurological deficits. MVNTs are distinctive tumors that should be differentiated from ganglion cell tumors, dysembryoplastic neuroepithelial tumors, and malformation of cortical development.

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Acknowledgments

We are grateful to Dr. Marc K. Rosenblum (New York, NY) for confirming the diagnosis. This work was supported in part by the National Cancer Center Research and Development Fund (26-A-9).

Conflicts of interest

The authors declare no conflicts of interest.

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Authors and Affiliations

  1. Division of Brain Tumor Translational Research, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan

    Shintaro Fukushima & Koichi Ichimura

  2. Department of Pathology and Clinical Laboratories, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan

    Shintaro Fukushima & Akihiko Yoshida

  3. Department of Neurosurgery and Neuro-Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan

    Yoshitaka Narita, Hideyuki Arita, Makoto Ohno, Yasuji Miyakita & Soichiro Shibui

Authors
  1. Shintaro Fukushima
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  2. Akihiko Yoshida
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  3. Yoshitaka Narita
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  4. Hideyuki Arita
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  5. Makoto Ohno
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  6. Yasuji Miyakita
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  7. Koichi Ichimura
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  8. Soichiro Shibui
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Correspondence to Akihiko Yoshida.

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Fukushima, S., Yoshida, A., Narita, Y. et al. Multinodular and vacuolating neuronal tumor of the cerebrum. Brain Tumor Pathol 32, 131–136 (2015). https://doi.org/10.1007/s10014-014-0198-9

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  • DOI: https://doi.org/10.1007/s10014-014-0198-9

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