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Epithelioid schwannoma

A case report with immunohistochemical and ultrastructural observations

  • Case Report
  • Published:
Annals of Diagnostic Paediatric Pathology

Abstract

A 17-year-old girl with epithelioid malignant peripheral nerve sheath tumor (MPNST) arising in the sural nerve is reported. The tumor grew in a nodular pattern and was composed of nests and solid trabeculi of tumor cells separated by hyaline stroma. Immunohisto-chemical reactions showed diffuse positivity for S-100 protein and co-expression of vimentin and GFAP in the entire tumor cell population. Cytokeratins (AE1/3) were expressed in scattered tumor cells. Immunohisto-chemistry revealed slender actin-positive stromal cells with long processes interposed between the hyaline matrix and the tumor cells. Ultrastructurally these cells were considered to be fibroblasts and myofibroblasts; others had features of primitive mesenchymal cells, a finding interpreted as a state of low differentiation of the stromal cells. The clinical course of the disease was recurrent and progressive with subsequent lymph node metastases and widespread dissemination. It correlated with an increased mitotic rate and PCNA positivity of the tumor cells at the metastatic sites.

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Author notes

  1. Roman Kodet

    Present address: Department of Pathology, 2nd School of Medicine, Charles University, V úvalu 84, CZ-150 06 Praha 5-Motol, Czech Republic

Authors and Affiliations

  1. Department of Pathology, 2nd School of Medicine, Charles University, and the University Hospital Motol, Prague, Czech Republic

    Roman Kodet

  2. Department of Pediatric Neurosurgery, 2nd School of Medicine, Charles University, and the University Hospital Motol, Prague, Czech Republic

    Michal Tichý

  3. Department of Pediatric Oncology, 2nd School of Medicine, Charles University, and the University Hospital Motol, Prague, Czech Republic

    Pavel Boček

Authors
  1. Roman Kodet
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  2. Michal Tichý
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  3. Pavel Boček
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Kodet, R., Tichý, M. & Boček, P. Epithelioid schwannoma. Ann Diagn Paed Pathol 2, 19–26 (1998). https://doi.org/10.1007/s100570050004

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  • DOI: https://doi.org/10.1007/s100570050004

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