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The existence of phonatory instability in multiple sclerosis: an acoustic and electroglottographic study

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Abstract

Dysarthria and phonatory symptomatology are often reported by patients suffering from multiple sclerosis (MS), but have been poorly investigated, although related to life quality. The objective of the study was to investigate the phonatory function in MS patients using objective measures. The speech of 64 MS patients and 64 pair-matched controls was recorded and analyzed using electroglottography, a physiological method that measures the electrical conductance during the opening and closing phases of the vibrating vocal folds. Electroglottographic parameters were correlated with clinical and MRI features. Most of the variables that have been used for the analysis of voice (vocal jitter P = 0.041, standard deviation of the average fundamental frequency P = 0.018, and the mean fundamental frequency of the vibrating vocal folds P = 0.025) differentiated the MS group from the control group. Phonatory function is impaired in MS patients, and physiological methods, such as electroglottography, are useful tools to assess it.

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The authors certify that there is no actual or potential conflict of interest in relation to this article.

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Authors and Affiliations

  1. Department of Neurology, Athens Naval Hospital, Athens, Greece

    Kostas Konstantopoulos, Michail Vikelis & Dimos-Dimitrios Mitsikostas

  2. Department of Communication Sciences and Disorders, Idaho State University, Pocatello, USA

    John Anthony Seikel

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  1. Kostas Konstantopoulos
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  2. Michail Vikelis
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  3. John Anthony Seikel
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  4. Dimos-Dimitrios Mitsikostas
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Correspondence to Michail Vikelis.

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Konstantopoulos, K., Vikelis, M., Seikel, J.A. et al. The existence of phonatory instability in multiple sclerosis: an acoustic and electroglottographic study. Neurol Sci 31, 259–268 (2010). https://doi.org/10.1007/s10072-009-0170-3

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  • DOI: https://doi.org/10.1007/s10072-009-0170-3

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