Abstract
Migraine is a common neurological disease in the population and the most associated headache with mood disorder. Although the relationship between migraine and depression is well known, the reverse correlation between depression and migraine was observed but not well understood. The tight relationship between the two disturbances is also suggested by the efficacy of antidepressants for migraine treatment. Starting from these observations, we can presume that both migraine and depression have overlapping biological bases. The main target of antidepressant treatments belonging to the serotonin selective reuptake inhibitors (SSRI) type is the serotonin transporter (SERT); a well-studied polymorphic variant, in the promoter region of the gene (SERTPR), has been demonstrated to influence the availability of serotonin in the synaptic cleft. So, our group studied the possible role of the SERT as a risk factor, both for migraine and mood disorders, in a sample of 96 patients affected by both pathologies.
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References
Ferrari MD (1998) Migraine. Lancet 351:1043–1051. doi:S0140-6736(97)11370-8[pii]10.1016/S0140-6736(97)11370-8
Frediani F, Villani V (2007) Migraine and depression. Neurol Sci 28(Suppl 2):S161–S165. doi:10.1007/s10072-007-0771-7
Racchi M, Leone M, Porrello E, Rigamonti A, Govoni S, Sironi M, Montomoli C, Bussone G (2004) Familial migraine with aura: association study with 5-HT1B/1D, 5-HT2C, and hSERT polymorphisms. Headache 44:311–317. doi:10.1111/j.1526-4610.2004.04072.xHED04072[pii]
Breslau N, Schultz LR, Stewart WF, Lipton RB, Lucia VC, Welch KM (2000) Headache and major depression: is the association specific to migraine? Neurology 54:308–313
Marcus DA (1993) Serotonin and its role in headache pathogenesis and treatment. Clin J Pain 9:159–167
Kotani K, Shimomura T, Shimomura F, Ikawa S, Nanba E (2002) A polymorphism in the serotonin transporter gene regulatory region and frequency of migraine attacks. Headache 42:893–895
Smeraldi E, Serretti A, Artioli P, Lorenzi C, Catalano M (2006) Serotonin transporter gene-linked polymorphic region: possible pharmacogenetic implications of rare variants. Psychiatr Genet 16:153–158
Andreoli V, Cassano GB, Rossi R (2002) DSM-IV-TR. Manuale diagnostico e statistico dei disturbi mentali (Text Revision, Masson)
Marziniak M, Mossner R, Schmitt A, Lesch KP, Sommer C (2005) A functional serotonin transporter gene polymorphism is associated with migraine with aura. Neurology 64:157–159. doi:64/1/157[pii]10.1212/01.WNL.0000148597.52312.9E
Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, Egan MF, Weinberger DR (2002) Serotonin transporter genetic variation and the response of the human amygdala. Science 297:400–403
Serretti A, Mandelli L, Lorenzi C, Pirovano A, Olgiati P, Colombo C, Smeraldi E (2007) Serotonin transporter gene influences the time course of improvement of “core” depressive and somatic anxiety symptoms during treatment with SSRIs for recurrent mood disorders. Psychiatry Res 149:185–193
Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527–1531
Benedetti F, Serretti A, Colombo C, Campori E, Barbini B, Di Bella D, Smeraldi E (1999) Influence of a functional polymorphism within the promoter of the serotonin transporter gene on the effects of total sleep deprivation in bipolar depression. Am J Psychiatry 156:1450–1452
Smits KM, Smits LJ, Schouten JS, Stelma FF, Nelemans P, Prins MH (2004) Influence of SERTPR and STin2 in the serotonin transporter gene on the effect of selective serotonin reuptake inhibitors in depression: a systematic review. Mol Psychiatry 9:433–441
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Marino, E., Fanny, B., Lorenzi, C. et al. Genetic bases of comorbidity between mood disorders and migraine: possible role of serotonin transporter gene. Neurol Sci 31, 387–391 (2010). https://doi.org/10.1007/s10072-009-0183-y
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DOI: https://doi.org/10.1007/s10072-009-0183-y