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Circulating TNF-α levels increased and correlated negatively with IGF-I in postoperative cognitive dysfunction

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Abstract

Signaling pathways of tumor necrosis factor-α (TNF-α) and insulin-like growth factor-I (IGF-I) are found to be functionally interrelated in some experimental studies. IGF-I may be involved in the pathogenesis of postoperative cognitive dysfunction (POCD). In order to investigate the possible interaction of TNF-α and IGF-I in POCD, the plasma levels of IGF-I and TNF-α were determined in 44 patients under general anesthesia. As compared with non-POCD patients, POCD patients showed increased TNF-α and decreased IGF-I levels in plasma, as well as a significant negative correlation between TNF-α and IGF-I values. The present results suggest that interaction of increased TNF-α levels and decreased IGF-1 levels might lead to a vicious circle, which may contribute to POCD.

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Acknowledgements

We thank Professor Zhong for providing access to equipment.

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Authors and Affiliations

  1. Department of Anesthesiology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Zhizaoju Road, 639, Shanghai, 200011, China

    Jue Jiang, Xiang Lv, Bing Liang & Hong Jiang

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  1. Jue Jiang
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  2. Xiang Lv
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  3. Bing Liang
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  4. Hong Jiang
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Correspondence to Hong Jiang.

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The authors declare that they have no competing interests.

Funding

The authors received funding for this work from Shanghai Municipal Commission of Health and Family Planning, grant number: 201540104.

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Jiang, J., Lv, X., Liang, B. et al. Circulating TNF-α levels increased and correlated negatively with IGF-I in postoperative cognitive dysfunction. Neurol Sci 38, 1391–1392 (2017). https://doi.org/10.1007/s10072-017-2962-1

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  • DOI: https://doi.org/10.1007/s10072-017-2962-1

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