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Microbial treatment: the potential application for Parkinson’s disease

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Abstract

Alterations in the composition of the intestinal flora are associated with the pathophysiology of Parkinson’s disease (PD). More importantly, the possible cause-effect links between gut flora and PD pathogenesis have been identified using PD animal models. Recent studies have found that probiotics improve the symptoms associated with constipation in PD patients. In addition, fecal microbiota transplantation (FMT) was recently shown to provide a protective effect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)–induced neurotoxicity in mice. Effective microbial therapy for PD includes probiotics and FMT. Therefore, microbial therapy may be a useful and novel approach for treatment of PD. In this review, I discuss the use of microbial treatment in PD.

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Acknowledgments

I particularly appreciate the support of Ying Liu.

Funding

This work was supported by the National Natural Science Foundation of China (Grant No. 81660203) and the Natural Science Foundation of Jiangxi Province (Grant No. 20142BAB205092 and 20181BAB205030).

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  1. Department of Neurology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China

    Xin Fang

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  1. Xin Fang
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Correspondence to Xin Fang.

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Fang, X. Microbial treatment: the potential application for Parkinson’s disease. Neurol Sci 40, 51–58 (2019). https://doi.org/10.1007/s10072-018-3641-6

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  • DOI: https://doi.org/10.1007/s10072-018-3641-6

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