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Biomechanics of early cardiac development

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Abstract

Biomechanics affect early cardiac development, from looping to the development of chambers and valves. Hemodynamic forces are essential for proper cardiac development, and their disruption leads to congenital heart defects. A wealth of information already exists on early cardiac adaptations to hemodynamic loading, and new technologies, including high-resolution imaging modalities and computational modeling, are enabling a more thorough understanding of relationships between hemodynamics and cardiac development. Imaging and modeling approaches, used in combination with biological data on cell behavior and adaptation, are paving the road for new discoveries on links between biomechanics and biology and their effect on cardiac development and fetal programming.

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Authors and Affiliations

  1. Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, 97239, USA

    Sevan Goenezen & Sandra Rugonyi

  2. Heart Research Center, Oregon Health & Science University, Portland, OR, 97239, USA

    Monique Y. Rennie

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  1. Sevan Goenezen
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  2. Monique Y. Rennie
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  3. Sandra Rugonyi
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Correspondence to Sandra Rugonyi.

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Sevan Goenezen and Monique Y. Rennie contributed equally to this manuscript.

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Goenezen, S., Rennie, M.Y. & Rugonyi, S. Biomechanics of early cardiac development. Biomech Model Mechanobiol 11, 1187–1204 (2012). https://doi.org/10.1007/s10237-012-0414-7

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