Abstract
Seven diseases caused by pathotypes of Alternaria alternata, which produced host-selective toxins (HSTs), a diverse group of low-molecular-weight secondary metabolites, are known, and each HST has an essential role as a determinant of pathogenicity in all interactions between the plant host and A. alternata. Although these HST-producing pathotypes are morphologically indistinguishable, each has a distinct host range and can be distinguished by its specificity on the respective host plant, hence their designation as pathotypes of A. alternata. In 1933, Tanaka made the first discovery of a HST; fungus-free culture filtrates of A. kikuchiana (now called A. alternata Japanese pear pathotype) were toxic to susceptible cultivar Nijisseiki, but not to resistant cultivars. Over the 80 years since then, the structure of HST molecules, target sites and mode of actions of HSTs, and the molecular genetics of HST production regulating by supernumerary chromosomes encoding HST gene clusters have been studied extensively. We focus this review on studies of low-molecular-weight HSTs produced by A. alternata and give an overview of various types of HST studies.
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References
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Acknowledgments
The authors are deeply indebted to the late Dr. S. Nishimura and Dr. K. Kohmoto for their vision and efforts on Alternaria HST studies. This work was supported by Grants-in-Aids for Scientific Research (S) (21228001 to KA), Scientific Research (A) (23248007 to TT) and Scientific Research (B) (20380028 and 23380025 to MK) from the Japanese Society for Promotion of Sciences and Special Coordination Funds for Promoting Sciences from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.
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Akimitsu, K., Tsuge, T., Kodama, M. et al. Alternaria host-selective toxins: determinant factors of plant disease. J Gen Plant Pathol 80, 109–122 (2014). https://doi.org/10.1007/s10327-013-0498-7
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DOI: https://doi.org/10.1007/s10327-013-0498-7