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A Computational Parameter Study of Embryo Transfer

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Abstract

Embryo transfer (ET) is the final component of the in vitro fertilization process, and the limiting component to its success rate. The procedure is characterized by considerable technical variations in clinical practice and the effects of these different variations on the overall outcome is little understood. In this article we simulate the embryo transfer procedure based on a 2-dimensional fluid dynamics model and, in a large computational effort, we investigate the sensitivity of embryo placement on an array of procedural parameters. The results support the consensus among practitioners in what is the best choice of procedural factors. Based on the study we propose a set of optimal parameters with which to perform the ET procedure; in addition we suggest a novel technique of volume replacement prior to the catheter withdrawal.

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Acknowledgment

The authors are grateful to Professor Albert Milani for his interest, suggestions and encouragements.

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Authors and Affiliations

  1. Department of Mathematical Sciences, University of Wisconsin–Milwaukee, P.O. Box 413, Milwaukee, WI, 53201-0413, USA

    Istvan G. Lauko & Sava Dashev

  2. Reproductive Endocrinology and Infertility, University of California–San Francisco, 2356 Sutter Street, 7th Floor, San Francisco, CA, 94115, USA

    Paolo Rinaudo

Authors
  1. Istvan G. Lauko
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  2. Paolo Rinaudo
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  3. Sava Dashev
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Correspondence to Istvan G. Lauko.

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Lauko, I.G., Rinaudo, P. & Dashev, S. A Computational Parameter Study of Embryo Transfer. Ann Biomed Eng 35, 659–671 (2007). https://doi.org/10.1007/s10439-007-9259-0

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  • DOI: https://doi.org/10.1007/s10439-007-9259-0

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