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Role of p62 in the regulation of cell death induction

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Abstract

p62 is a multifunctional adaptor protein implicated in various cellular processes. It has been found to regulate selective autophagy, cell survival, cell death, oxidative stress, DNA repair and inflammation, and to play a role in a number of diseases, such as tumourigenesis, Paget’s disease of bone, neurodegenerative disease, diabetes, and obesity. Cell death induction is an important cellular process. The dysregulation of cell death induction is involved in the pathogenesis of various diseases, such as cancer, neurodegeneration diseases, and diabetes. In this review, we discuss the functional role of p62 in inducing cell death in response to multiple stimuli, and we summarize the potential signaling pathways that contribute to this regulation. Given the important role of p62 in regulating cell death, p62 is considered to be a reasonable target for managing cell death dysregulation-related pathogenic conditions. A better understanding of the role of p62 and its related mechanisms in regulating cell death is necessary for the more precise utilization of p62 as a target for treating relevant diseases.

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Acknowledgements

This work was supported by Grants from the National Natural Science Foundation of China (NSFC, 31371752 and 31671945). We thank Professor Douglas G. Mashek for his editorial assistance.

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Authors and Affiliations

  1. Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Veterinary Medicine, China Agricultural University, No. 2 Yuanmingyuan West Road, Haidian District, Beijing, 100193, China

    Lihong Fan

  2. Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, Beijing Key Laboratory for Food Non-Thermal Processing, China Agricultural University, No. 17 Qinghua East Road, Haidian District, Beijing, 100083, China

    Shutao Yin, Enxiang Zhang & Hongbo Hu

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  1. Lihong Fan
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Correspondence to Hongbo Hu.

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Fan, L., Yin, S., Zhang, E. et al. Role of p62 in the regulation of cell death induction. Apoptosis 23, 187–193 (2018). https://doi.org/10.1007/s10495-018-1445-z

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