Skip to main content

Advertisement

SpringerLink
Log in

The Molecular Genetic Expression as a Novel Biomarker in the Evaluation and Monitoring of Patients With Osteosarcoma-Subtype Bone Cancer Disease

  • Review
  • Published:
Biochemical Genetics Aims and scope Submit manuscript

Abstract

One of the leading causes of death among patients with malignancies is represented by bone cancer. According to current studies, the leading cause of death among these patients is represented by late diagnosis, poor response to therapy, and the lack of accuracy in terms of clinical evaluation. In this regard, there have been developed a series of methods of diagnosis and evaluation, the most investigated being represented by miRNA expression. In this updated work, we want to present a series of changes in the expression of miRNAs in bone cancer. Moreover, we want to present the implications of miRNAs in targeted therapy in such patients. Studies available in scientific databases such as PubMed and Scopus were examined. The studies were searched using the keywords “miRNAs expression”, “bone cancer”, “genetic therapy” and “genetic biomarkers.” For the evaluation and monitoring of bone cancer, the expression of miRNAs can be successfully used due to increased specificity. Using miRNAs as gene therapy can be also considered a therapeutic method of the future, mainly due to selective and targeted response of the body.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  • Bao Y, Yi Y, Peng L et al (2013) Roles of microRNA-206 in osteosarcoma pathogenesis and progression. Asian Pac J Cancer Prev 14(6):3751–3755

    Article  PubMed  Google Scholar 

  • Bedreag OH, Rogobete AF, Dumache R et al (2015) The use of circulating microRNAs as biomarkers in critically ill polytrauma patient. A review. Biomark Genom Med 7:131–138

    Article  CAS  Google Scholar 

  • Bedreag OH, Rogobete AF, Cradigati CA et al (2016a) A novel evaluation of microvascular damage in critically ill polytrauma patients by using circulating microRNAs. Rev Rom Med Lab 24(1):21–30

    Google Scholar 

  • Bedreag OH, Sandesc D, Chiriac SD et al (2016b) The use of circulating miRNAs as biomarkers for oxidative stress in critically ill polytrauma patients. Clin Lab 62(3):263–274

    CAS  PubMed  Google Scholar 

  • Bratu LM, Rogobete AF, Papurica M et al (2016) Literature research regarding miRNAs’ expression in the assessment and evaluation of the critically ill polytrauma patient with traumatic brain and spinal cord injury. Clin Lab 62(10):2019–2024

    PubMed  Google Scholar 

  • Cai H, Lin L, Cai H et al (2013) Prognostic evaluation of microRNA-210 expression in pediatric osteosarcoma. Med Oncol 30:499

    Article  PubMed  Google Scholar 

  • Calin GA, Cimmino A, Fabbri M et al (2008) miR-15a and miR-16-1 cluster functions in human leukemia. Proc Natl Acad Sci 105:5166–5171

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cho K, Wang X, Nie S et al (2008) Therapeutic nanoparticles for drug delivery in cancer. Clin Cancer Res 14:1310–1316

    Article  CAS  PubMed  Google Scholar 

  • Dong J, Liu Y, Liao W et al (2016) miRNA-223 is a potential diagnostic and prognostic marker for osteosarcoma. J Bone Oncol 5:74–79

    Article  PubMed  PubMed Central  Google Scholar 

  • Duan Z, Choy E, Harmon D et al (2011) MicroRNA-199a-3p is downregulated in human osteosarcoma and regulates cell proliferation and migration. Mol Cancer Ther 10(8):1337–1345

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dylla L, Moore C, Jedlicka P (2013) MicroRNAs in Ewing sarcoma. Front Oncol 28(3):65

    Google Scholar 

  • Fey V, Ka S, Pollari S et al (2012) Identification of MicroRNAs inhibiting TGF- b-induced IL-11 production in bone metastatic breast cancer cells. PLoS ONE 7(5):e37361

    Article  PubMed  PubMed Central  Google Scholar 

  • Ji F, Zhang H, Wang Y et al (2013) MicroRNA-133a, downregulated in osteosarcoma, suppresses proliferation and promotes apoptosis by targeting Bcl-xL and Mcl-1. Bone 56:220–226

    Article  CAS  PubMed  Google Scholar 

  • Jiang X, Li X, Wu F et al (2017) Overexpression of miR-92a promotes the tumor growth of osteosarcoma by suppressing F-box and WD repeat-containing protein 7. Gene 606:10–16. doi:10.1016/j.gene.2017.01.002

    Article  CAS  PubMed  Google Scholar 

  • Kawano M, Tanaka K, Itonaga I, Iwasaki T, Tsumura H (2015) c-Myc represses tumor-suppressive microRNAs, let-7a, miR-16 and miR-29b, and induces cyclin D2-Mediated cell proliferation in Ewing’s sarcoma cell line. PLoS ONE 10(9):e0138560

    Article  PubMed  PubMed Central  Google Scholar 

  • Kinase C, Huang S, Han Z, Cao K (2014) Let-7a functions as a tumor suppressor in Ewing’ s sarcoma cell lines partly by targeting. DNA Cell Biol 33(3):136–147

    Article  Google Scholar 

  • Li R, Wang L (2016) Decreased microRNA-452 expression and its prognostic significance in human osteosarcoma. World J Surg Oncol 18(14):150

    Article  Google Scholar 

  • Li W, Wu H, Li Y et al (2016) Science direct MicroRNA-143 promotes apoptosis of osteosarcoma cells by caspase-3 activation via targeting Bcl-2. Biomed Pharmacother 80:8–15

    Article  CAS  PubMed  Google Scholar 

  • Lian F, Cui Y, Zhou C et al (2015) Identification of a plasma four-microRNA panel as potential noninvasive biomarker for osteosarcoma. PLoS ONE 10(3):e0121499

    Article  PubMed  PubMed Central  Google Scholar 

  • Lian D, Wang Z, Liu N (2016) MicroRNA-1908 is a biomarker for poor prognosis in human osteosarcoma. Eur Rev Med Pharmacol Sci 20(7):1258–1262

    CAS  PubMed  Google Scholar 

  • Liu W, Zhao Z, Shi L, Yuan W (2015) Tissue microRNA-126 expression level predicts outcome in human osteosarcoma. Diagn Pathol 21(10):116

    Article  Google Scholar 

  • Mohan S, Thiagarajan K, Chandrasekaran R, Arul J (2014) In vitro protection of biological macromolecules against oxidative stress and in vivo toxicity evaluation of Acacia nilotica (L.) and ethyl gallate in rats. BMC Complement Altern Med 14:257

    Article  PubMed  PubMed Central  Google Scholar 

  • Namløs HM, Meza-zepeda LA, Barøy T et al (2012) Modulation of the osteosarcoma expression phenotype by microRNAs. PLoS ONE 7(10):e48086

    Article  PubMed  PubMed Central  Google Scholar 

  • Papurica M, Rogobete AF, Sandesc D et al (2015) Redox changes induced by general anesthesia in critically ill patients with multiple traumas. Mol Biol Int 2015:238586

    Article  PubMed  PubMed Central  Google Scholar 

  • Papurica M, Rogobete AF, Sandesc D et al (2016) The expression of nuclear transcription factor kappa B (NF-κB) in the case of critically Ill polytrauma patients with sepsis and its interactions with microRNAs. Biochem Genet 54(4):337–347

    Article  CAS  PubMed  Google Scholar 

  • Poulsen RC, Knowles HJ, Carr AJ, Hulley PA (2014) Cell differentiation versus cell death: extracellular glucose is a key determinant of cell fate following oxidative stress exposure. Cell Death Dis 5:e1074

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pu Y, Zhao F, Cai W, Meng X (2016) MiR-193a-3p and miR-193a-5p suppress the metastasis of human osteosarcoma cells by down-regulating Rab27B and SRR, respectively. Clin Exp Metastasis 33:359–372

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rippo MR, Olivieri F, Monsurrò V et al (2014) MitomiRs in human inflamm-aging: a hypothesis involving miR-181a, miR-34a and miR-146a. Exp Gerontol 56:154–163

    Article  CAS  PubMed  Google Scholar 

  • Rogobete AF, Bedreag OH, Popovici SE et al (2016) Detection of myocardial injury using miRNAs expression as genetic biomarkers in acute cardiac care. J Cardiovasc Emerg 2(4):169–172

    Google Scholar 

  • Schnetzke U, Spies-Weisshart B, Yomade O et al (2015) Polymorphisms of Toll-like receptors (TLR2 and TLR4) are associated with the risk of infectious complications in acute myeloid leukemia. Genes Immun 16:83–88

    Article  CAS  PubMed  Google Scholar 

  • Song B, Wang Y, Xi Y et al (2009) Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cells. Oncogene 28(46):4065–4074

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sun B, Yang M, Li M, Wang F (2015a) Science direct The microRNA-217 functions as a tumor suppressor and is frequently downregulated in human osteosarcoma. Biomed Pharmacother 71:58–63

    Article  CAS  PubMed  Google Scholar 

  • Sun T, Kalionis B, Lv G et al (2015b) Role of exosomal noncoding RNAs in lung carcinogenesis. Biomed Res Int 2015:125807

    PubMed  PubMed Central  Google Scholar 

  • Sun M, Zhou X, Chen L et al (2016) The regulatory roles of microRNAs in bone remodeling and perspectives as biomarkers in osteoporosis. Biomed Res Int 2016:1652417

    PubMed  PubMed Central  Google Scholar 

  • Tang J, Zhao H, Cai H, Wu H (2015) Science direct diagnostic and prognostic potentials of microRNA-27a in osteosarcoma. Biomed Pharmacother 71:222–226

    Article  CAS  PubMed  Google Scholar 

  • Ticlea M, Melania L, Bodog F, Horea O (2016) The use of exosomes as biomarkers for evaluating and monitoring critically Ill polytrauma patients with sepsis. Biochem Genet 55(1):1–9

    Article  PubMed  Google Scholar 

  • Van Driel M, Van Leeuwen JPTM (2014) Cancer and bone: a complex complex. Arch Biochem Biophys 561:159–166

    Article  Google Scholar 

  • Vimalraj S, Miranda PJ, Ramyakrishna B, Selvamurugan N (2013) Regulation of breast cancer and bone metastasis by MicroRNAs. Dis Mark 35(5):369–387

    Article  CAS  Google Scholar 

  • Wang Y, Yue B, Yu X et al (2013) SLUG is activated by nuclear factor kappa B and confers human alveolar epithelial A549 cells resistance to tumor necrosis factor-alpha-induced apoptosis. World J Surg Oncol 11:12

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang Z, Cai H, Lin L et al (2014) Upregulated expression of microRNA-214 is linked to tumor progression and adverse prognosis in pediatric osteosarcoma. Pediatr Blood Cancer 61:206–210

    Article  PubMed  Google Scholar 

  • Xu S, Yang Y, Han S, Wu Z (2014) MicroRNA-9 expression is a prognostic biomarker in patients with osteosarcoma. World J Surg Oncol 12:195

    Article  PubMed  PubMed Central  Google Scholar 

  • Yang Z, Zhang Y, Zhang X et al (2015) Science direct serum microRNA-221 functions as a potential diagnostic and prognostic marker for patients with osteosarcoma. Biomed Pharmacother 75:153–158

    Article  CAS  PubMed  Google Scholar 

  • Zhang HAO, Wang Y, Xu T et al (2016) Increased expression of microRNA-148a in osteosarcoma promotes cancer cell growth by targeting PTEN. Oncol Lett 12(5):3208–3214

    PubMed  PubMed Central  Google Scholar 

  • Zoni E, Van Der Pluijm G (2016) The role of microRNAs in bone metastasis. J Bone Oncol 5:104–108

    Article  PubMed  PubMed Central  Google Scholar 

  • Zou P, Ding J, Fu S (2016) Elevated expression of microRNA-19a predicts a poor prognosis in patients with osteosarcoma. Pathol Res Pract. doi:10.1016/j.prp.2016.12.020

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Faculty of Chemistry, Biology, Geography, West University of Timisoara, Timisoara, Romania

    Delia Hutanu

  2. Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania

    Roxana Popescu, Horatiu Stefanescu, Laurentiu Pirtea, Cristi Sarau, Ovidiu Boruga, Lagtonbi Mehdi, Ioana Ciuca & Sonia Tanasescu

  3. Faculty of Dental Medicine, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania

    Adrian Candea

Authors
  1. Delia Hutanu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Roxana Popescu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Horatiu Stefanescu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Laurentiu Pirtea
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Adrian Candea
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Cristi Sarau
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Ovidiu Boruga
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Lagtonbi Mehdi
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Ioana Ciuca
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Sonia Tanasescu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ovidiu Boruga.

Ethics declarations

Conflict of interest

The authors have declared no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hutanu, D., Popescu, R., Stefanescu, H. et al. The Molecular Genetic Expression as a Novel Biomarker in the Evaluation and Monitoring of Patients With Osteosarcoma-Subtype Bone Cancer Disease. Biochem Genet 55, 291–299 (2017). https://doi.org/10.1007/s10528-017-9801-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10528-017-9801-1

Keywords

Search

Navigation