Abstract
Lymphovascular invasion (LVI) in gastric cancer is readily demonstrated pre-operatively by mucosal biopsy during endoscopy, which can also provide samples for gene expression profiling. We have examined gene expression associated with lymphovascular invasion in a cohort of gastric cancer patients and have developed a 28-gene predictor of tumor aggressiveness for forecasting risk of node positivity (N+), which could potentially be useful pre-operatively. The resulting model’s ranking of increasing tumor aggressiveness correlated positively with N+ status, reaching statistical significance, and was three times the correlation of LVI with N+ status.
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Acknowledgments
CEC is Canada Research Chair in Oncology. Funding support to the PolyomX Program was provided by the Alberta Cancer Foundation and the Alberta Cancer Board and through the Clinical Investigator Program of the Royal College of Physicians and Surgeons of Canada and the University of Alberta Hospital Foundation to BJD.
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Korenberg, M.J., Dicken, B.J., Damaraju, S. et al. Predicting node positivity in gastric cancer from gene expression profiles. Biotechnol Lett 31, 1381–1388 (2009). https://doi.org/10.1007/s10529-009-0035-0
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DOI: https://doi.org/10.1007/s10529-009-0035-0