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Expression patterns of insulin-like growth factor 1 (IGF-I) and its receptor in mammary tissues and their associations with breast cancer survival

  • Epidemiology
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Abstract

The level of circulating insulin-like growth factor 1 (IGF-I) has been shown to be positively associated with breast cancer risk. The expression patterns of the IGF-I and its receptor IGFIR genes in breast tissues and their association with breast cancer survival remain unclear. In the present study, we quantified the mRNA levels of the IGF-I and IGFIR genes in both benign and malignant breast tumor tissues and their adjacent normal tissues. We then evaluated whether the expression patterns of these genes in breast cancer tissues are related to breast cancer survival. Included in the study were samples from 508 patients diagnosed with primary breast cancer, and 206 patients diagnosed with benign breast disease (BBD). Patients with BBD had a significantly higher IGF-I gene expression than patients with breast cancer in both tumor and adjacent non-neoplastic tissues. Among BBD patients, mRNA levels of the IGF-I gene were similar between tumor and tumor adjacent tissues. In cancer patients, however, the expression levels of these genes were substantially higher in tumor adjacent tissues than in tumor tissues. Patients with a high expression of the IGF-I gene in cancer tissues tended to have more favorable overall and disease-free survival. Our findings suggest that the expression of IGF-I and IGFIR genes may undergo substantial change over the course of breast tumorigenesis, and the pattern of changes may be associated with breast cancer prognosis.

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Acknowledgments

The authors wish to thank Dr Qi Dai and Ms Jia-Rong Cheng for their contributions in coordinating data and specimen collection in Shanghai, Dr Wanqing Wen for statistical support in data analysis, and Ms Brandy Bentley for technical assistance in the preparation of this manuscript. This study would not have been possible without the support of all of the study participants and research staff of the Shanghai Breast Cancer Study. This study is supported by USPHS Grant RO1CA64277 and RO1CA90899 from the National Cancer Institute.

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Authors and Affiliations

  1. Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University, S1121 Medical Center North, 1161 21st Avenue S., Nashville, TN, 37232-2587, USA

    Aesun Shin, Xiao-Ou Shu, Qiuyin Cai & Wei Zheng

  2. Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China

    Yu-Tang Gao

  3. Guangzhou Metro Center for Disease Control and Prevention, Guangzhou, China

    Zefang Ren

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  1. Aesun Shin
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  2. Zefang Ren
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  3. Xiao-Ou Shu
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  4. Qiuyin Cai
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  5. Yu-Tang Gao
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  6. Wei Zheng
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Correspondence to Wei Zheng.

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Shin, A., Ren, Z., Shu, XO. et al. Expression patterns of insulin-like growth factor 1 (IGF-I) and its receptor in mammary tissues and their associations with breast cancer survival. Breast Cancer Res Treat 105, 55–61 (2007). https://doi.org/10.1007/s10549-006-9427-1

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  • DOI: https://doi.org/10.1007/s10549-006-9427-1

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