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Is there association between left atrial function and functional capacity in patients with uncomplicated type 2 diabetes?

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Abstract

We sought to investigate the relationship between phasic left atrial function (LA) and functional capacity in the patients with type 2 diabetes (DM). This cross-sectional investigation included 72 controls and 64 uncomplicated DM subjects. All participants underwent echocardiographic examination and cardiopulmonary exercise testing. Total and passive LA emptying fractions (EF), demonstrating LA reservoir and conduit function, were significantly lower in DM patients than in controls. Active LA EF, the parameter of LA booster pump function, was similar between DM and controls. Total and positive LA strains, corresponding with reservoir and conduit function, were also significantly reduced in DM subjects comparing with controls. However, negative LA strain—parameter of LA booster pump function, was significantly increased in DM patients in comparison with controls. Peak oxygen consumption was significantly reduced and ventilation/carbon dioxide slope was elevated in DM patients. In the whole study population LA global longitudinal strain was associated with heart rate recovery in the first minute, peak oxygen consumption and ventilation/carbon dioxide slope independently of other clinical parameters and LV hypertrophy and LV diastolic function. In conclusion, LA phasic function and functional capacity were significantly impaired in the patients with DM. LA longitudinal strain, but not LA volume index, was independently related with functional capacity in the whole study population. Our results suggest that evaluation of LA function and functional capacity could detect subclinical target organ damage and prevent development of further complications in uncomplicated DM patients.

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Author notes

  1. Vladan Vukomanovic and Jelena Suzic-Lazic have contributed equally.

Authors and Affiliations

  1. Department of Cardiology, University Clinical Hospital Center “Dr. Dragisa Misovic - Dedinje”, Heroja Milana Tepica 1, 11000, Belgrade, Serbia

    Vladan Vukomanovic, Jelena Suzic-Lazic, Vera Celic, Vladimir Djukic & Marijana Tadic

  2. Clinical Research Unit, University of Milan-Bicocca and Istituto Auxologico Italiano IRCCS, Viale della Resistenza 23, 20036, Meda, Italy

    Cesare Cuspidi

  3. Department of Medicine and Surgery, Clinica Medica, University Milano-Bicocca, Milan, Italy

    Guido Grassi

  4. IRCCS Multimedica, Sesto San Giovanni, Milan, Italy

    Guido Grassi

  5. Department of Advanced Biomedical Sciences, Federico II University Hospital, Naples, Italy

    Maurizio Galderisi

  6. Department of Internal Medicine and Cardiology, Charité – Universitätsmedizin Berlin, Campus Virchow-Klinikum, Augustenburgerplatz 1, 13353, Berlin, Germany

    Marijana Tadic

Authors
  1. Vladan Vukomanovic
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  2. Jelena Suzic-Lazic
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  3. Vera Celic
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  4. Cesare Cuspidi
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  5. Guido Grassi
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  6. Maurizio Galderisi
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  7. Vladimir Djukic
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  8. Marijana Tadic
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Correspondence to Marijana Tadic.

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Vukomanovic, V., Suzic-Lazic, J., Celic, V. et al. Is there association between left atrial function and functional capacity in patients with uncomplicated type 2 diabetes?. Int J Cardiovasc Imaging 36, 15–22 (2020). https://doi.org/10.1007/s10554-019-01680-z

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  • DOI: https://doi.org/10.1007/s10554-019-01680-z

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