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Sperm Cryopreservation in Male Infertility Due to Genetic Disorders

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Abstract

Certain chromosomal and genetic anomalies, such as Klinefelter syndrome (47,XXY) and Y chromosome microdeletions, have been reported as potential causes of a progressive impairment of spermatogenesis. In these cases cryoconservation of ejaculated or testicular sperm represent a valuable tool for the preservation of fertility. However, dealing with genetic disorders, the transmission of genetic anomalies has to be taken into consideration. It is therefore important to be aware about the clinical importance and the related genetic risks of these anomalies. In this article we describe the clinical significance of these diseases.

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References

  • J.R. Aitken J.A. Marshall (2002) ArticleTitleThe future of sex Nature 415 IssueID6875 963 Occurrence Handle11875544 Occurrence Handle1:CAS:528:DC%2BD38Xhsl2ltL8%3D Occurrence Handle10.1038/415963a

    Article  PubMed  CAS  Google Scholar 

  • R.A. Brandell A. Mielnik D. Liotta Z. Ye L.L. Veeck G.D. Palermo P.N. Schlegel (1998) ArticleTitleAZFb deletions predict the absence of spermatozoa with testicular sperm extraction: preliminary report of a prognostic genetic test Hum. Reprod. 13 2812–2815 Occurrence Handle9804236 Occurrence Handle1:CAS:528:DyaK1cXntFCitrs%3D

    PubMed  CAS  Google Scholar 

  • A.E. Calogero M.R. Garofalo N. Barone A. Palma ParticleDe E. Vicari R. Romeo S. Tumino R. D’Agata (2001) ArticleTitleSpontaneous regression over time of the germinal epithelium in a Y chromosome-microdeleted patient: case report Hum. Reprod. 16 1845–1848 Occurrence Handle11527886 Occurrence Handle1:STN:280:DC%2BD3MvosFOluw%3D%3D Occurrence Handle10.1093/humrep/16.9.1845

    Article  PubMed  CAS  Google Scholar 

  • S. Cayan D. Lee L.D. Black R.A. Reijo Pera P.J. Turek (2001) ArticleTitleResponse to varicocelectomy in oligospermic men with and without defined genetic infertility Urology 57 IssueID3 530–535 Occurrence Handle11248633 Occurrence Handle1:STN:280:DC%2BD3M3islKgsg%3D%3D Occurrence Handle10.1016/S0090-4295(00)01015-3

    Article  PubMed  CAS  Google Scholar 

  • D.S. Cram K. Ma S. Bhasin J. Arias M. Pandjaitan B. Chu M.S. Audrins D. Saunders F. Quinn D. deKretser R. McLachlan (2000) ArticleTitleY chromosome analysis of infertile men and their sons conceived through intracytoplasmic sperm injection: vertical transmission of deletions and rarity of de novo deletions Fertil. Steril. 74 909–915 Occurrence Handle11056231 Occurrence Handle1:STN:280:DC%2BD3M%2Fkt12qsA%3D%3D Occurrence Handle10.1016/S0015-0282(00)01568-5

    Article  PubMed  CAS  Google Scholar 

  • S. Fernandes K. Huellen J. Goncalves H. Dukal J. Zeisler E. Rajpert De Meyts N.E. Skakkebaek B. Habermann W. Krause M. Sousa A. Barros P.H. Vogt (2002) ArticleTitleHigh frequency of DAZ1/DAZ2 gene deletions in patients with severe oligozoospermia Mol. Hum. Reprod. 8 286–298 Occurrence Handle11870237 Occurrence Handle1:CAS:528:DC%2BD38XislSmsLw%3D Occurrence Handle10.1093/molehr/8.3.286

    Article  PubMed  CAS  Google Scholar 

  • S. Fernandes S. Paracchini L.H. Meyer G. Floridia C. Tyler-Smith P.H. Vogt (2004) ArticleTitleA large AZFc deletion removes DAZ3/DAZ4 and nearby genes from men in Y haplogroup N Am. J. Hum. Genet. 74 180–187 Occurrence Handle14639527 Occurrence Handle1:CAS:528:DC%2BD2cXlvVOqsg%3D%3D Occurrence Handle10.1086/381132

    Article  PubMed  CAS  Google Scholar 

  • C. Foresta A. Ferlin A. Garolla E. Moro M. Pistorello S. Barbaux M. Rossato (1998) ArticleTitleHigh frequency of well-defined Y-chromosome deletions in idiopathic Sertoli cell-only syndrome Hum. Reprod. 13 302–307 Occurrence Handle9557827 Occurrence Handle1:CAS:528:DyaK1cXitlGhtrg%3D Occurrence Handle10.1093/humrep/13.2.302

    Article  PubMed  CAS  Google Scholar 

  • C. Foresta A. Bettella E. Moro M. Rossato M. Merico A. Garolla A. Ferlin (2002) ArticleTitleInhibin B plasma concentrations in infertile patients with DAZ gene deletions treated with FSH Eur. J. Endocrinol. 146 801–806 Occurrence Handle12039700 Occurrence Handle1:CAS:528:DC%2BD38Xlt1KmsrY%3D Occurrence Handle10.1530/eje.0.1460801

    Article  PubMed  CAS  Google Scholar 

  • L. Frydelund-Larsen C. Krausz H. Leffers A.M. Andersson E. Carlsen S. Bangsboell K. McElreavey N.E. Skakkebaek E. Rajpert-De Meyts (2002) ArticleTitleInhibin B: a marker for the functional state of the seminiferous epithelium in patients with azoospermia factor C microdeletions J. Clin. Endocrinol. Metab. 87 5618–5624 Occurrence Handle12466362 Occurrence Handle1:CAS:528:DC%2BD38XpslWnur4%3D Occurrence Handle10.1210/jc.2002-020737

    Article  PubMed  CAS  Google Scholar 

  • C. Giachini E. Guarducci G. Longepied S. Degl’Innocenti L. Becherini G. Forti M.J. Mitchell C. Krausz (2005) ArticleTitleThe gr/gr deletion(s): a new genetic test in male infertility? J. Med. Genet. 42 497–502 Occurrence Handle15937085 Occurrence Handle1:CAS:528:DC%2BD2MXmt1Citbs%3D Occurrence Handle10.1136/jmg.2004.028191

    Article  PubMed  CAS  Google Scholar 

  • C.V. Hopps A. Mielnik M. Goldstein G.D. Palermo Z. Rosenwaks P.N. Schlegel (2003) ArticleTitleDetection of sperm in men with Y chromosome microdeletions of the AZFaAZFb and AZFc regions Hum. Reprod. 18 1660–1665 Occurrence Handle12871878 Occurrence Handle1:CAS:528:DC%2BD3sXlvF2ru7k%3D Occurrence Handle10.1093/humrep/deg348

    Article  PubMed  CAS  Google Scholar 

  • M.C. Jiang Y.R. Lien S.U. Chen T.M. Ko H.N. Ho Y.S. Yang (1999) ArticleTitleTransmission of de novo mutations of the deleted in azoospermia genes from a severely oligozoospermic male to a son via intracytoplasmic sperm injection Fertil. Steril. 71 1029–1032 Occurrence Handle10360905 Occurrence Handle1:STN:280:DyaK1M3oslKmsg%3D%3D Occurrence Handle10.1016/S0015-0282(99)00150-8

    Article  PubMed  CAS  Google Scholar 

  • A. Kamischke J. Gromoll M. Simoni H.M. Behre E. Nieschlag (1999) ArticleTitleTransmission of a Y chromosomal deletion involving the deleted in azoospermia (DAZ) and chromodomain (CDY1) genes from father to son through intracytoplasmic sperm injection: case report Hum. Reprod. 14 2320–2322 Occurrence Handle10469702 Occurrence Handle1:STN:280:DyaK1MvgtVOitA%3D%3D Occurrence Handle10.1093/humrep/14.9.2320

    Article  PubMed  CAS  Google Scholar 

  • A. Kamischke A. Baumgardt J. Horst E. Nieschlag (2003) ArticleTitleClinical and diagnostic features of patients with suspected Klinefelter syndrome J. Androl. 24 IssueID1 41–48 Occurrence Handle12514081

    PubMed  Google Scholar 

  • C. Kamp P. Hirschmann H. Voss K. Huellen P.H. Vogt (2000) ArticleTitleTwo long homologous retroviral sequence blocks in proximal Yq11 cause AZFa microdeletions as a result of intrachromosomal recombination events Hum. Mol. Genet. 9 2563–2572 Occurrence Handle11030762 Occurrence Handle1:CAS:528:DC%2BD3cXnslGqs74%3D Occurrence Handle10.1093/hmg/9.17.2563

    Article  PubMed  CAS  Google Scholar 

  • C. Kamp K. Huellen S. Fernandes M. Sousa P.N. Schlegel A. Mielnik S. Kleiman H. Yavetz W. Krause W. Kupker R. Johannisson W. Schulze W. Weidner A. Barros P.H. Vogt (2001) ArticleTitleHigh deletion frequency of the complete AZFa sequence in men with Sertoli-cell-only syndrome Mol. Hum. Reprod. 7 987–994 Occurrence Handle11574668 Occurrence Handle1:CAS:528:DC%2BD3MXnvVGhtrs%3D Occurrence Handle10.1093/molehr/7.10.987

    Article  PubMed  CAS  Google Scholar 

  • M.G. Kent-First S. Kol A. Muallem R. Ofir D. Manor S. Blazer N. First J. Itskovitz-Eldor (1996) ArticleTitleThe incidence and possible relevance of Y-linked microdeletions in babies born after intracytoplasmic sperm injection and their infertile fathers Mol. Hum. Reprod. 2 943–950 Occurrence Handle9237238 Occurrence Handle1:CAS:528:DyaK2sXhs1Okt7o%3D

    PubMed  CAS  Google Scholar 

  • S.E. Kleiman B. Bar-Shira Maymon L. Yogev G. Paz H. Yavetz (2001) ArticleTitleThe prognostic role of the extent of Y microdeletion on spermatogenesis and maturity of Sertoli cells Hum. Reprod. 16 399–402 Occurrence Handle11228202 Occurrence Handle1:STN:280:DC%2BD3M3jsFSguw%3D%3D Occurrence Handle10.1093/humrep/16.3.399

    Article  PubMed  CAS  Google Scholar 

  • S.E. Kleiman L. Yogev R. Gamzu R. Hauser A. Botchan G. Paz J.B. Lessing Y. Yaron H. Yavetz (1999) ArticleTitleThree-generation evaluation of Y-chromosome microdeletion J. Androl. 20 394–398 Occurrence Handle10386819 Occurrence Handle1:CAS:528:DyaK1MXktFOiurY%3D

    PubMed  CAS  Google Scholar 

  • C. Krausz C. Bussani-Mastellone S. Granchi K. McElreavey G. Scarselli G. Forti (1999a) ArticleTitleScreening for microdeletions of Y chromosome genes in patients undergoing intracytoplasmic sperm injection Hum. Reprod. 14 1717–1721 Occurrence Handle1:CAS:528:DyaK1MXlsVGjsL0%3D Occurrence Handle10.1093/humrep/14.7.1717

    Article  CAS  Google Scholar 

  • C. Krausz L. Quintana-Murci S. Barbaux J.-P. Siffroi H. Rouba D. Delafontaine N. Souleyreau-Therville G. Arvis J.M. Antoine E. Erdei J.P. Taar A. Tar E. Jeandidier G. Plessis T. Bourgeron J.-P. Dadoune M. Fellous K. McElreavey (1999b) ArticleTitleA high frequency of Y chromosome deletions in males with non-idiopathic infertility J. Clin. Endocrinol. Metab. 84 IssueID10 3606–3612 Occurrence Handle1:CAS:528:DyaK1MXms1OhtLs%3D Occurrence Handle10.1210/jc.84.10.3606

    Article  CAS  Google Scholar 

  • C. Krausz G. Forti K. McElreavey (2003) ArticleTitleThe Y chromosome and male fertility and infertility Int. J. Androl. 26 IssueID2 70–75 Occurrence Handle12641824 Occurrence Handle10.1046/j.1365-2605.2003.00402.x

    Article  PubMed  Google Scholar 

  • C. Krausz K. McElreavey (1999) ArticleTitleY chromosome and male infertility Front. Biosci. 4 E1–E8 Occurrence Handle9889182 Occurrence Handle1:CAS:528:DyaK1MXitFKisb0%3D

    PubMed  CAS  Google Scholar 

  • C. Krausz K. McElreavey (2001) ArticleTitleY chromosome microdeletions in “fertile” males Hum. Reprod. 6 1306 Occurrence Handle10.1093/humrep/16.6.1306

    Article  Google Scholar 

  • C. Krausz L. Quintana-Murci K. McElreavey (2000) ArticleTitlePrognostic value of Y deletion analysis: what is the clinical prognostic value of Y chromosome microdeletion analysis? Hum. Reprod. 15 1431–1434 Occurrence Handle10875846 Occurrence Handle1:STN:280:DC%2BD3cvivVGntQ%3D%3D Occurrence Handle10.1093/humrep/15.7.1431

    Article  PubMed  CAS  Google Scholar 

  • C. Krausz E. Rajpert-De Meyts L.F. Larsen L. Quintana-Murci K. McElreavey N. Skakkebaek (2001) ArticleTitleDouble blind screening for microdeletions of Y chromosome genes in infertile and fertile/normospermic Danish men J. Clin. Endocrinol. Metab. 86 2638–2642 Occurrence Handle11397865 Occurrence Handle1:CAS:528:DC%2BD3MXms1Oitb8%3D Occurrence Handle10.1210/jc.86.6.2638

    Article  PubMed  CAS  Google Scholar 

  • J.A. Marshall (2000) ArticleTitleHuman Y chromosomesex determination, and spermatogenesis-a feminist view Biol. Reprod. 63 667–676 Occurrence Handle10.1095/biolreprod63.3.667

    Article  Google Scholar 

  • J.P. Mulhall R. Reijo R. Alagappan L. Brown D. Page R. Carson R.D. Oates (1997) ArticleTitleAzoospermic men with deletion of the DAZ gene cluster are capable of completing spermatogenesis: fertilization, normal embryonic development and pregnancy occur when retrieved testicular spermatozoa are used for intracytoplasmic sperm injection Hum. Reprod. 12 503–508 Occurrence Handle9130751 Occurrence Handle1:STN:280:ByiB2sjgsFw%3D Occurrence Handle10.1093/humrep/12.3.503

    Article  PubMed  CAS  Google Scholar 

  • J. Nielsen M. Wohlert (1991) ArticleTitleChromosome abnormalities found among 34,910 newborn children: results from a 13-year incidence study in Arhus, Denmark Hum. Genet. 87 IssueID1 81–83 Occurrence Handle2037286 Occurrence Handle1:STN:280:By6B2cvivV0%3D Occurrence Handle10.1007/BF01213097

    Article  PubMed  CAS  Google Scholar 

  • E. Nieschlag H.M. Behre D. Meschede A. Kamischke (2000) Disorders at the testicular level E. Nieschlag H.M. Behre (Eds) Andrology: Male Reproductive Health and Dysfunction EditionNumber2 Sprinter Heidelberg 133–159

    Google Scholar 

  • R.D. Oates S. Silber L.G. Brown D.C. Page (2002) ArticleTitleClinical characterization of 42 oligospermic or azoospermic men with microdeletion of the AZFc region of the Y chromosomeand of 18 children conceived via ICSI Hum. Reprod. 17 2813–2824 Occurrence Handle12407032 Occurrence Handle1:CAS:528:DC%2BD38XptFOrtb4%3D Occurrence Handle10.1093/humrep/17.11.2813

    Article  PubMed  CAS  Google Scholar 

  • H. Okada H. Fujioka N. Tatsumi M. Kanzaki Y. Okuda M. Fujisawa M. Hazama O. Matsumoto K. Gohji S. Arakawa S. Kamidono (1999) ArticleTitleKlinefelter’s syndrome in the male infertility clinic Hum. Reprod. 14 IssueID4 946–952 Occurrence Handle10221225 Occurrence Handle1:STN:280:DyaK1M3jslGrsA%3D%3D Occurrence Handle10.1093/humrep/14.4.946

    Article  PubMed  CAS  Google Scholar 

  • D.C. Page S. Silber L.G. Brown (1999) ArticleTitleMen with infertility caused by AZFc deletion can produce sons by intracytoplasmic sperm injection, but are likely to transmit the deletion and infertility Hum. Reprod. 14 1722–1726 Occurrence Handle10402375 Occurrence Handle1:STN:280:DyaK1MzjtVKmug%3D%3D Occurrence Handle10.1093/humrep/14.7.1722

    Article  PubMed  CAS  Google Scholar 

  • P.C. Patsalis C. Sismani L. Quintana-Murci F. Taleb-Bekkouche C. Krausz K. McElreavey (2002) ArticleTitleEffects of transmission of Y chromosome AZFc deletions Lancet 360 1222–1224 Occurrence Handle12401251 Occurrence Handle1:CAS:528:DC%2BD38XotVWgsbg%3D Occurrence Handle10.1016/S0140-6736(02)11248-7

    Article  PubMed  CAS  Google Scholar 

  • B. Peterlin T. Kunej J. Sinkovec N. Gligorievska B. Zorn (2002) ArticleTitleScreening for Y chromosome microdeletions in 226 Slovenian subfertile men Hum. Reprod. 17 IssueID1 17–24 Occurrence Handle11756356 Occurrence Handle1:CAS:528:DC%2BD38Xht1WlsL8%3D Occurrence Handle10.1093/humrep/17.1.17

    Article  PubMed  CAS  Google Scholar 

  • S. Repping H. Skaletsky L. Brown S.K. Daalen Particlevan C.M. Korver T. Pyntikova T. Kuroda-Kawaguchi J.W. Vries Particlede R.D. Oates S. Silber F. Veen Particlevan der D.C. Page S. Rozen (2003) ArticleTitlePolymorphism for a 1.6-Mb deletion of the human Y chromosome persists through balance between recurrent mutation and haploid selection Nat. Genet. 35 247–251 Occurrence Handle14528305 Occurrence Handle1:CAS:528:DC%2BD3sXosFWrtrw%3D Occurrence Handle10.1038/ng1250

    Article  PubMed  CAS  Google Scholar 

  • S. Repping H. Skaletsky J. Lange S. Silber F. Veen Particlevan der R.D. Oates D.C. Page S. Rozen (2002) ArticleTitleRecombination between palindromes P5 and P1 on the human Y chromosome causes massive deletions and spermatogenic failure Am. J. Hum. Genet. 71 906–922 Occurrence Handle12297986 Occurrence Handle10.1086/342928

    Article  PubMed  Google Scholar 

  • M. Rossato A. Ferlin A. Garolla M. Pistorello C. Foresta (1998) ArticleTitleCase report: high fertilization rate in conventional in-vitro fertilization utilizing spermatozoa from an oligozoospermic subject presenting microdeletions of the Y chromosome long arm Hum. Reprod. 4 473–476 Occurrence Handle1:STN:280:DyaK1czivVGksg%3D%3D Occurrence Handle10.1093/molehr/4.5.473

    Article  CAS  Google Scholar 

  • J.P. Siffroi C. Le Bourhis C. Krausz S. Barbaux L. Quintana-Murci S. Kanafani H. Rouba L. Bujan G. Bourrouillou I. Seifer D. Boucher M. Fellous K. McElreavey J.P. Dadoune (2000) ArticleTitleSex chromosome mosaicism in males carrying Y chromosome long arm deletions Hum. Reprod. 15 2559–2562 Occurrence Handle11098026 Occurrence Handle1:STN:280:DC%2BD3M%2FoslWntQ%3D%3D Occurrence Handle10.1093/humrep/15.12.2559

    Article  PubMed  CAS  Google Scholar 

  • S.J. Silber R. Alagappan L.G. Brown D.C. Page (1998) ArticleTitleY Chromosome deletions in azoospermic and severely oligozoospermic men undergoing intracytoplasmic sperm injection after testicular sperm extraction Hum. Reprod. 13 3332–3337 Occurrence Handle9886509 Occurrence Handle1:CAS:528:DyaK1MXltFOmuw%3D%3D Occurrence Handle10.1093/humrep/13.12.3332

    Article  PubMed  CAS  Google Scholar 

  • M. Simoni E. Bakker M.C. Eurlings G. Matthijs E. Moro C.R. Muller P.H. Vogt (1999) ArticleTitleLaboratory guidelines for molecular diagnosis of Y-chromosomal microdeletions Int. J. Androl. 22 292–299 Occurrence Handle10509229 Occurrence Handle1:CAS:528:DyaK1MXms1ylu78%3D Occurrence Handle10.1046/j.1365-2605.1999.00193.x

    Article  PubMed  CAS  Google Scholar 

  • H. Skaletsky T. Kuroda-Kawaguchi P.J. Minx H.S. Cordum L. Hillier L.G. Brown S. Repping T. Pyntikova J. Ali T. Bieri A. Chinwalla A. Delehaunty K. Delehaunty H. Du G. Fewell L. Fulton R. Fulton T. Graves S.F. Hou P. Latrielle S. Leonard E. Mardis R. Maupin J. McPherson T. Miner W. Nash C. Nguyen P. Ozersky K. Pepin S. Rock T. Rohlfing K. Scott B. Schultz C. Strong A. Tin-Wollam S.P. Yang R.H. Waterston R.K. Wilson S. Rozen D.C. Page (2003) ArticleTitleThe male-specific region of the human Y chromosome is a mosaic of discrete sequence classes Nature 423 825–837 Occurrence Handle12815422 Occurrence Handle1:CAS:528:DC%2BD3sXks1Kmtbk%3D Occurrence Handle10.1038/nature01722

    Article  PubMed  CAS  Google Scholar 

  • C. Staessen H. Tournaye E. Assche ParticleVan A. Michiels L. Landuyt ParticleVan P. Devroey I. Liebaers A. Steirteghem ParticleVan (2003) ArticleTitlePGD in 47,XXY Klinefelter’s syndrome patients Hum. Reprod. Update 9 IssueID4 319–330 Occurrence Handle12926526 Occurrence Handle1:STN:280:DC%2BD3szovFaktQ%3D%3D Occurrence Handle10.1093/humupd/dmg029

    Article  PubMed  CAS  Google Scholar 

  • L. Tiepolo O. Zuffardi (1976) ArticleTitleLocalization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm Hum. Genet. 34 119–124 Occurrence Handle1002136 Occurrence Handle1:STN:280:CSiD2s%2FivFU%3D Occurrence Handle10.1007/BF00278879

    Article  PubMed  CAS  Google Scholar 

  • P.A. Tomasi R. Oates L. Brown G. Delitala D.C. Page (2003) ArticleTitleThe pituitary–testicular axis in Klinefelter’s syndrome and in oligo-azoospermic patients with and without deletions of the Y chromosome long arm Clin. Endocrinol. (Oxf) 59 214–222 Occurrence Handle10.1046/j.1365-2265.2003.01828.x

    Article  Google Scholar 

  • H. Tournaye C. Staessen I. Liebaers E. Assche ParticleVan P. Devroey M. Bonduelle A. Steirteghem ParticleVan (1996) ArticleTitleTesticular sperm recovery in nine 47,XXY Klinefelter patients Hum. Reprod. 11 IssueID8 1644–1649 Occurrence Handle8921109 Occurrence Handle1:STN:280:ByiD2sbjslM%3D

    PubMed  CAS  Google Scholar 

  • K. Ven Particlevan der M. Montag B. Peschka J. Leygraaf G. Schwanitz G. Haidl D. Krebs H. Ven Particleder (1997) ArticleTitleCombined cytogenetic and Y chromosome microdeletion screening in males undergoing intracytoplasmic sperm injection Mol. Hum. Reprod. 3 699–704 Occurrence Handle9294854 Occurrence Handle10.1093/molehr/3.8.699

    Article  PubMed  Google Scholar 

  • R.J. Golde Particlevan A.M. Wetzels R. Graaf Particlede J.H. Tuerlings D.D. Braat J.A. Kremer (2001) ArticleTitleDecreased fertilization rate and embryo quality after ICSI in oligozoospermic men with microdeletions in the azoospermia factor c region of the Y chromosome Hum. Reprod. 16 289–292 Occurrence Handle11157822 Occurrence Handle10.1093/humrep/16.2.289

    Article  PubMed  Google Scholar 

  • P.H. Vogt A. Edelmann S. Kirsch O. Henegariu P. Hirschmann F. Kiesewetter F.M. Kohn W.B. Schill S. Farah C. Ramos M. Hartmann W. Hartschuh D. Meschede H.M. Behre A. Castel E. Nieschlag W. Weidner H.J. Grone A. Jung W. Engel G. Haidl (1996) ArticleTitleHuman Y chromosome azoospermia factors (AZF) mapped to different subregions in Yq11 Hum. Mol. Genet. 5 933–943 Occurrence Handle8817327 Occurrence Handle1:CAS:528:DyaK28Xkt1Cntrk%3D Occurrence Handle10.1093/hmg/5.7.933

    Article  PubMed  CAS  Google Scholar 

  • G. Westlander E. Ekerhovd S. Granberg L. Hanson C. Hanson C. Bergh (2001) ArticleTitleTesticular ultrasonography and extended chromosome analysis in men with nonmosaic Klinefelter syndrome: a prospective study of possible predictive factors for successful sperm recovery Fertil. Steril. 75 IssueID6 1102–1105 Occurrence Handle11384633 Occurrence Handle1:STN:280:DC%2BD3MzhtFyntA%3D%3D Occurrence Handle10.1016/S0015-0282(01)01793-9

    Article  PubMed  CAS  Google Scholar 

  • G. Westlander E. Ekerhovd C. Bergh (2003) ArticleTitleLow levels of serum inhibin B do not exclude successful sperm recovery in men with nonmosaic Klinefelter syndrome Fertil. Steril. 79Suppl 3 IssueIDSuppl 3 1680–1682 Occurrence Handle10.1016/S0015-0282(03)00403-5

    Article  Google Scholar 

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  1. Andrology Unit, Department of Clinical Physiopathology, Viale Pieraccini, 6, Firenze, Italy

    Csilla Krausz & Gianni Forti

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  1. Csilla Krausz
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Krausz, C., Forti, G. Sperm Cryopreservation in Male Infertility Due to Genetic Disorders. Cell Tissue Banking 7, 105–112 (2006). https://doi.org/10.1007/s10561-005-1967-9

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