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New insights into childhood leukemia etiology

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References

  1. Barrington-Trimis JL, Cockburn M, Metayer C, Gauderman WJ, Wiemels J, McKean-Cowdin R. Rising rates of acute lymphoblastic leukemia in Hispanic children: trends in incidence from 1992 to 2011. Blood. 2015;125(19):3033–4. doi:10.1182/blood-2015-03-634006.

    Article  PubMed  CAS  Google Scholar 

  2. Greaves MF, Wiemels J. Origins of chromosome translocations in childhood leukaemia. Nat Rev Cancer. 2003;3(9):639–49.

    Article  PubMed  CAS  Google Scholar 

  3. Gruhn B, Taub JW, Ge Y, et al. Prenatal origin of childhood acute lymphoblastic leukemia, association with birth weight and hyperdiploidy. Leukemia. 2008;22(9):1692–7. doi:10.1038/leu.2008.152.

    Article  PubMed  CAS  Google Scholar 

  4. Mori H, Colman SM, Xiao Z, et al. Chromosome translocations and covert leukemic clones are generated during normal fetal development. Proc Natl Acad Sci USA. 2002;99(12):8242–7.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  5. Papaemmanuil E, Rapado I, Li Y, et al. RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia. Nat Genet. 2014;46(2):116–25. doi:10.1038/ng.2874.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  6. Swaminathan S, Klemm L, Park E, et al. Mechanisms of clonal evolution in childhood acute lymphoblastic leukemia. Nat Immunol. 2015;16(7):766–74. doi:10.1038/ni.3160.

    Article  PubMed  CAS  Google Scholar 

  7. Kinlen L. Evidence for an infective cause of childhood leukaemia: comparison of a Scottish new town with nuclear reprocessing sites in Britain. Lancet. 1988;2(8624):1323–7.

    Article  PubMed  CAS  Google Scholar 

  8. Greaves M. Infection, immune responses and the aetiology of childhood leukaemia. Nat Rev Cancer. 2006;6(3):193–203.

    Article  PubMed  CAS  Google Scholar 

  9. Lupatsch JE, Kuehni CE, Niggli F, Ammann RA, Egger M, Spycher BD. Population mixing and the risk of childhood leukaemia in Switzerland: a census-based cohort study. Eur J Epidemiol. 2015. doi:10.1007/s10654-015-0042-5.

    Google Scholar 

  10. Kinlen LJ. Population mixing and childhood leukaemia. Eur J Epidemiol (Letter to the editor). 2015. doi:10.1007/s10654-015-0107-5.

  11. Kreis C, Grotzer M, Hengartner H, Spycher BD, Swiss Paediatric Oncology G, Swiss National Cohort Study G. Space-time clustering of childhood cancers in Switzerland: a nationwide study. Int J Cancer. 2015. doi:10.1002/ijc.29955.

    PubMed  Google Scholar 

  12. Chang JS, Tsai CR, Tsai YW, Wiemels JL. Medically diagnosed infections and risk of childhood leukaemia: a population-based case-control study. Int J Epidemiol. 2012;41(4):1050–9. doi:10.1093/ije/dys113.

    Article  PubMed  Google Scholar 

  13. Crouch S, Lightfoot T, Simpson J, Smith A, Ansell P, Roman E. Infectious illness in children subsequently diagnosed with acute lymphoblastic leukemia: modeling the trends from birth to diagnosis. Am J Epidemiol. 2012;176(5):402–8. doi:10.1093/aje/kws180.

    Article  PubMed  Google Scholar 

  14. Amitay EL, Keinan-Boker L. Breastfeeding and childhood leukemia incidence: a Meta-analysis and systematic review. JAMA Pediatr. 2015;169(6):e151025. doi:10.1001/jamapediatrics.2015.1025.

    Article  PubMed  Google Scholar 

  15. Crump C, Sundquist J, Sieh W, Winkleby MA, Sundquist K. Perinatal risk factors for acute myeloid leukemia. Eur J Epidemiol. 2015. doi:10.1007/s10654-015-0063-0.

    PubMed  Google Scholar 

  16. Meister K, Johansson C, Forsberg B. Estimated short-term effects of coarse particles on daily mortality in Stockholm, Sweden. Environ Health Perspect. 2012;120(3):431–6. doi:10.1289/ehp.1103995.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  17. Spycher BD, Feller M, Roosli M, et al. Childhood cancer and residential exposure to highways: a nationwide cohort study. Eur J Epidemiol. 2015. doi:10.1007/s10654-015-0091-9.

    Google Scholar 

  18. Horan JT, Hsle H, Meshinchi S. Acute Myeloid Leukemia. In: Smith RO, Reamon GH, Racadio JM, editors. Hematopoietic cell transplantation in children with cancer. New York: Springer; 2013.

    Google Scholar 

  19. Pendleton M, Lindsey RH Jr, Felix CA, Grimwade D, Osheroff N. Topoisomerase II and leukemia. Ann N Y Acad Sci. 2014;1310:98–110. doi:10.1111/nyas.12358.

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  20. Sergentanis TN, Thomopoulos TP, Gialamas SP, et al. Risk for childhood leukemia associated with maternal and paternal age. Eur J Epidemiol. 2015. doi:10.1007/s10654-015-0089-3.

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Authors and Affiliations

  1. Program in Pediatric Malignancies, UCSF Helen Diller Cancer Center, 1450 3rd Street, MC0520, San Francisco, CA, 94158, USA

    Joe Wiemels

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  1. Joe Wiemels
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Correspondence to Joe Wiemels.

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Wiemels, J. New insights into childhood leukemia etiology. Eur J Epidemiol 30, 1225–1227 (2015). https://doi.org/10.1007/s10654-015-0115-5

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  • DOI: https://doi.org/10.1007/s10654-015-0115-5

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