Abstract
Symptoms of autism spectrum disorder (ASD) were assessed (Social Responsiveness Scale-Parent (SRS-P); coded in-session behavior) in typically-developing, anxiety-disordered children (N = 50) treated with cognitive-behavioral therapy (CBT). Study 1: children with moderate autistic symptomology (per SRS-P) were significantly more likely to improve from family CBT (FCBT) than individual CBT (ICBT; OR = 8.67). Coded behavior did not predict outcome. Study 2: CBT components were compared by treatment and ASD symptom status. At-home exposure completion was greater in FCBT and there was an interaction in child involvement for treatment and ASD status. Though both treatments reduced anxiety, FCBT outperformed ICBT for children with moderate ASD symptoms, a benefit potentially linked to more at-home exposures and greater child involvement in FCBT.
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Notes
A closer examination of therapist treatment adherence in the original RCT revealed that therapists, based on others ratings, may have unintentionally employed some CBT within the FESA condition. This “bleeding” between the CBT and control conditions questioned the distinctiveness of the FESA treatment and its candidacy for further analysis in this study.
References
American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington D.C.: American Psychiatric Association.
Barmish, A., & Kendall, P. C. (2005). Should parents be co-clients in cognitive-behavioral therapy for anxious youth? Journal of Clinical Child and Adolescent Psychology, 34, 569–581.
Campbell, M., Schopler, E., Cueva, J. E., & Hallin, A. (1996). Treatment of autistic disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 35, 134–143.
Cartwright-Hatton, S., Roberts, C., Chitsabesan, P., Fothergill, C., & Harrington, R. (2004). Systematic review of the efficacy of cognitive behaviour therapies for childhood and adolescent anxiety disorders. British Journal of Clinical Psychology, 43, 421–436.
Chalfant, A. M., Rapee, R., & Carroll, L. (2006). Treating anxiety disorders in children with high functioning autism spectrum disorders: A controlled trial. Journal of Autism and Developmental Disorders, 37, 1842–1857.
Chavira, D. A., Stein, M. B., Bailey, K., & Stein, M. T. (2004). Comorbidity of generalized social anxiety disorder and depression in a pediatric primary care sample. Journal of Affective Disorders, 80, 163–171.
Chu, B. C., & Kendall, P. C. (2004). Positive association of child involvement and treatment outcome within a manual-based cognitive-behavioral treatment for children with anxiety. Journal of Consulting and Clinical Psychology, 25, 821–829.
Cobham, V. E., Dadds, M. R., & Spence, S. H. (1998). The role of parental anxiety in the treatment of childhood anxiety. Journal of Consulting and Clinical Psychology, 66, 893–905.
Constantino, J., Davis, S. A., Reich, W., Schindler, M. K., Gross, M. M., Brophy, S. L., et al. (2003a). Validation of a brief quantitative measure of autistic traits: Comparison of the social responsiveness scale with the autism diagnostic interview–revised. Journal of Autism and Developmental Disorders, 33, 427–433.
Constantino, J. N., & Gruber, C. P. (2005). Social Responsiveness Scale (SRS) Manual. Los Angeles, CA: Western Psychological Services.
Constantino, J. N., Gruber, C. P., Davis, A., Hayes, S., Passanante, N., & Przybeck, T. (2004). The factor structure of autistic traits. Journal of Child Psychology and Psychiatry, 45, 719–726.
Constantino, J. N., Hudziak, J., & Todd, R. (2003b). Deficits in reciprocal social behavior in male twins: Evidence for genetically independent domain of psychopathology. Journal of the American Academy of Child and Adolescent Psychiatry, 42, 458–467.
Constantino, J. N., & Todd, R. (2003). Autistic traits in the general population: A twin study. Archives of General Psychiatry, 60, 524–530.
Crawley, S. A., Beidas, R. S., Benjamin, C. L., Martin, E., & Kendall, P. C. (2008). Treating socially phobic youth with CBT: Differential outcomes and treatment considerations. Behavioural and Cognitive Therapy, 36, 379–389.
Farrugia, S., & Hudson, J. (2006). Anxiety in adolescents with Asperger syndrome: Negative thoughts, behavioral problems and life interference. Focus on Autism and Other Developmental Disabilities, 21, 25–35.
Filipek, P. A., Pasquale, J. A., Baranek, G. T., Cook, E. H., Dawson, D., Gordon, B., et al. (1999). The screening and diagnosis of autistic spectrum disorders. Journal of Autism and Developmental Disorders, 29, 439–484.
Gillott, A., Furniss, F., & Walter, A. (2001). Anxiety in high-functioning children with autism. Autism, 5, 277–286.
Green, J., Gilchrist, A., Burton, D., & Cox, A. (2000). Social and psychiatric functioning in adolescents with Asperger syndrome compared with conduct disorder. Journal of Autism and Developmental Disorders, 30, 279–293.
Howard, B., Chu, B., Krain, A., Marrs-Garcia, A., & Kendall, P. C. (2000). Cognitive-behavioral family therapy for anxious children: Therapist manual. Ardmore, PA: Workbook Publishing.
Hudson, J. (2007). Efficacy of cognitive–behavioural therapy for children and adolescents with anxiety disorders. Behaviour Change, 22, 50–77.
Kendall, P. C., & Hedtke, K. (2006). Cognitive-behavioral therapy for anxious children: Therapist manual (3rd ed.). Ardmore, PA: Workbook Publishing.
Kendall, P. C., Hudson, J., Gosch, E., Flannery-Schroeder, E., & Suveg, C. (2008). Cognitive-behavioral therapy for anxiety disordered youth: A randomized clinical trial evaluating child and family modalities. Journal of Consulting and Clinical Psychology, 76, 282–297.
Khanna, M. S., & Kendall, P. C. (2009). Exploring the role or parent training in the treatment of childhood anxiety. Journal of Consulting and Clinical Psychology, 77, 981–986.
Loovas, I. O., Koegal, R., Simmons, J. Q., & Long, J. S. (1973). Some generalization and follow-up measures on autistic children in behavior therapy. Journal of Applied Behavior Analysis, 6, 131–166.
Lord, C., Risi, S., Lambrecht, L., Cook, E., Leventhal, B., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223.
Lord, C., Rutter, M., & LeCouteur, A. (1994). Autism diagnostic interview-revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 19, 185–212.
March, J. S., & Albano, A. (1998). New developments in assessing pediatric anxiety disorders. Advances in Clinical Child Psychology, 20, 213–241.
Micali, N., Chakrabarti, S., & Fombonne, E. (2004). The broader autism phenotype: Findings from an epidemiological study. Autism, 8, 21–37.
Pine, D. S., Guyer, A. E., Goldwin, M., Towbin, K. A., & Leibenluft, A. (2008). Autism spectrum disorder scale scores in pediatric mood and anxiety disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 47, 652–661.
Podell, J. C., Mychailyszyn, M., Edmunds, J., Puleo, C. M., & Kendall, P. C. (2010). The Coping Cat Program for anxious youth: The FEAR plan comes to life. Cognitive and Behavioral Practice, 17, 132–141.
Reaven, J., Blakeley-Smith, A., Nichols, S., Dasari, M., Flanigan, E., & Hepburn, S. (2009). Cognitive behavioral group treatment for anxiety symptoms in children with high-functioning autism spectrum disorders: A pilot study. Focus on Autism and Other Developmental Disabilities, 24, 27–37.
Reaven, J., & Hepburn, S. (2003). Cognitive-Behavioral treatment of obsessive-compulsive disorder in a child with Asperger syndrome: A case report. Autism, 7, 145–164.
Shirk, S. R., & Karver, M. (2003). Prediction of treatment outcome form relationship variables in child and adolescent therapy: A meta analytic review. Evidenced Based Mental Health, 71, 452–464.
Silverman, W. K., & Albano, A. M. (1996). Anxiety Disorders Interview Schedule for DSM-IV: Child and Parent Versions. Boulder, CO: Graywind Publications. Incorporated.
Silverman, W. K., Saaverdra, L. M., & Pina, A. A. (2001). Test-retest reliability of anxiety symptoms and diagnoses with anxiety disorders interview schedule for DSM-IV: Child and parent versions. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 937–944.
Sofronoff, K., Attwood, T., & Hinton, S. (2005). A randomized controlled trial of a CBT intervention for anxiety in children with Asperger syndrome. Journal of Child Psychology and Psychiatry, 46, 1152–1160.
Southam-Gerow, M. A., Kendall, P. C., & Weersing, V. R. (2001). Examining outcome variability: Correlates of treatment response in a child and adolescent anxiety clinic. Journal of Clinical Child Psychology, 30, 422–436.
Steffenburg, S., Gillburg, C., & Steffenburg, U. (1996). Psychiatric disorders in children and adolescents with mental retardation and active epilepsy. Archives of Neurology, 53, 904–912.
Sukhodolsky, D. G., Scahill, L., Gadow, K. D., Arnold, L. E., Aman, M. G., et al. (2008). Parent-rated anxiety symptoms in children with pervasive developmental disorders: Frequency and association with core autism symptoms and cognitive functioning. Journal of Abnormal Child Psychology, 36, 117–128.
Sze, K. M., & Wood, J. J. (2007). Cognitive behavioral treatment of comorbid anxiety disorders and social difficulties in children with high-functioning autism: A case report. Journal of Contemporary Psychotherapy, 37, 133–143.
Vila, G., Nollet-Clemencon, C., de Blic, J., Mouren-Simeoni, M., & Scheinmann, P. (2000). Prevalence of DSM-IV anxiety and affective disorders in a pediatric population of asthmatic children and adolescents. Journal of Affective Disorders, 58, 223–231.
Volkmar, F. R., Paul, R., Klin, A., & Cohen, D. (2005). Handbook of Autism and Pervasive Developmental Disorders, 3rd edition, Volume one: Diagnosis, development, neurobiology and behavior. Wiley: Hoboken, NJ.
Walkup, J., Albano, A. M., Piacentini, J., Birmaher, B., Compton, S., Sherrill, J., et al. (2008). Cognitive behavioral therapy, sertraline, or a combination in childhood anxiety. New England Journal of Medicine, 359, 2753–2766.
White, S. W., Oswald, D., Ollendick, T., & Scahill, L. (2009). Anxiety in children and adolescents with autism spectrum disorders. Clinical Psychology Review, 29, 216–229.
Wood, J. J., Drahota, A., Sze, K., Har, K., Chiu, A., & Langer, D. A. (2009). Cognitive behavioral therapy for anxiety in children with autism spectrum disorders: A randomized, controlled trial. Child Psychology and Psychiatry, 50, 224–234.
Wood, J. J., Piacentini, J. C., Bergman, R. L., McCracken, J., & Barrios, V. (2002). Concurrent validity of the anxiety disorders section of the anxiety disorders interview schedule for DSM-IV: Child and parent versions. Journal of Clinical Child and Adolescent Psychology, 31, 335–342.
Wood, J. J., Piacentini, J. C., Southam-Gerow, M., Chu, B. C., & Sigman, M. (2006). Family cognitive behavioral therapy for child anxiety disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 45, 314–321.
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This research was supported by NIMH grant (MH59087) awarded to the second author.
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Puleo, C.M., Kendall, P.C. Anxiety Disorders in Typically Developing Youth: Autism Spectrum Symptoms as a Predictor of Cognitive-Behavioral Treatment. J Autism Dev Disord 41, 275–286 (2011). https://doi.org/10.1007/s10803-010-1047-2
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DOI: https://doi.org/10.1007/s10803-010-1047-2